Orientation adaptation and perceptual learning change orientation tuning curves of V1 cells. Adaptation shifts tuning curve peaks away from the adapted orientation, reduces tuning curve slopes near the adapted orientation, and increases the responses on the far flank of tuning curves. Learning an orientation discrimination task increases tuning curve slopes near the trained orientation. These c...

Blood sample processing and handling can have a significant impact on the stability and levels of proteins measured in biomarker studies. Such pre-analytical variability needs to be well understood in the context of the different proteomics platforms available for biomarker discovery and validation. In the present study we evaluated different types of blood collection tubes including the BD P10...

High-resolution magnetic resonance microscopy (MRM) was used to determine regional brain volumetric changes in a mouse model of Alzheimer's disease. These transgenic (Tg) mice overexpress human mutant amyloid precursor protein (APP) V717F under control of platelet-derived growth factor promoter (PDAPP mice), and cortical and hippocampal beta-amyloid (Abeta) deposits accumulate in heterozygotes ...

Many lives and aircrafts have been lost due to human errors associated with mental workload overload (MWLOL). Human are successfully considered in existing Fault Tree Analysis (FTA) methods. However, MWLOL is through Performance Shaping Factors indirectly its information hidden FT construction, which not conducive analyze the root causes of risks. To overcome this difficulty, we develop a risk ...

Music copyrights are not only considered as commodities but also private property which must be recognized and protected by the state. In Indonesia, legal protection for copyright holders creators is conducted through National Collective Management Organization, while in Malaysia those issues handled Rights Berhad. The purpose of this research using a comparative concept approach to provide inf...

Hepatocellular carcinoma (HCC) is one of the most common and aggressive cancers and is associated with a poor survival rate. Clinically, the level of alpha-fetoprotein (AFP) has been used as a biomarker for the diagnosis of HCC. The discovery of useful biomarkers for HCC, focused solely on the proteome, has been difficult; thus, wide-ranging global data mining of genomic and proteomic databases...

Multiple reaction monitoring (MRM) of peptides uses tandem mass spectrometry to quantify selected proteins of interest, such as those previously identified in differential studies. Using this technique, the specificity of precursor to product transitions is harnessed for quantitative analysis of multiple proteins in a single sample. The design of transitions is critical for the success of MRM e...

Introduction Myocardial blood flow (MBF) measurement in humans using arterial spin labeling (ASL) shows promise but has produced highly variable results [1-4]. One critical source of measurement errors is the physiological noise caused by static tissue mis-registration due to metabolic fluctuation, respiratory and cardiac motion, and other unknown variations over time [5]. Background suppressio...

In the visuomotor mental rotation (VMR) task, participants point to a location that deviates from a visual target by a predetermined angle. A seminal investigation of the VMR task reported a linear increase in reaction time (RT) as a function of increasing angle, for 5°, 10°, 15°, 35°, 70°, 105°, and 140° (Georgopoulos and Massey, 1987). This finding led to the development of the mental rotatio...

Whether number of examed lymph nodes (ELNs) would bring survival benefit for patients with negative lymph nodes after modified radical mastectomy (MRM) is uncertain. In our study, using the Surveillance Epidemiology and End Results (SEER) database between 2004 and 2009, we screened the appropriate patients with negative lymph nodes underwent MRM. The Cox proportional hazard analysis was used to...