BACKGROUND Anti-angiogenic treatment in recurrent glioblastoma patients suppresses contrast enhancement and reduces vasogenic edema while non-enhancing tumor progression is common. Thus, the importance of T2-weighted imaging is increasing. We therefore quantified T2 relaxation times, which are the basis for the image contrast on T2-weighted images. METHODS Conventional and quantitative MRI pr...

INTRODUCTION: For delivery of MRI reporter genes (e.g. ferritin) to the rodent brain, lentiviral (LV) and adeno-associated viral (AAV) vectors are the preferred viral vector systems when aiming for stable, long-term labelling and in vivo visualization of cells. However, their potential limitations for MRI like the generation of unspecific contrast by the vector injection and host response are o...

A mathematical model was applied to new lesion formation in multiple sclerosis, as apparent on frequent T2-weighted MRI. The pathophysiologically motivated two-process model comprises two opposing nonlinear self-limiting processes, intended to represent degenerative and reparatory processes, respectively, investigating T2 activity from a dynamic/temporal rather than a spatial/static perspective...

Magnetic resonance imaging (MRI) provides non-invasive, repetitive measures in the same individual, allowing the study of a physio-pathological event over time. In this study, we tested the performance of 7 Tesla multi-parametric MRI to monitor the dynamic changes of mouse skeletal muscle injury and regeneration upon acute ischemia induced by femoral artery dissection. T2-mapping (T2 relaxation...

BACKGROUND Facioscapulohumeral muscular dystrophy (FSHD) is one of the most common muscular dystrophies and is characterized by a non-conventional genetic mechanism activated by pathogenic D4Z4 repeat contractions. By muscle Magnetic Resonance Imaging (MRI) we observed that T2-short tau inversion recovery (T2-STIR) sequences identify two different conditions in which each muscle can be found be...

Quantitative nuclear magnetic resonance imaging (MRI) has been considered a promising non-invasive tool for monitoring therapeutic essays in small size mouse models of muscular dystrophies. Here, we combined MRI (anatomical images and transverse relaxation time constant-T2-measurements) to texture analyses in the study of four mouse strains covering a wide range of dystrophic phenotypes. Two st...

INTRODUCTION Mismatch of diffusion/perfusion by MRI has been used as an estimate of the ischemic penumbra, but there are large parts of the mismatch region appear not to at risk, even though they may contribute to functional impairment (1). It was also reported that some of the apparent diffusion coefficient (ADC) reduction area can be salvaged by early reperfusion. It is essential to find a me...

BACKGROUND A few studies have found that abnormal findings on diffusion-weighted magnetic resonance imaging (MRI) are useful for diagnosing cerebral fat embolism in the acute stage. CASE REPORT We applied serial MRI to a case of cerebral fat embolism with cognitive impairment lasting for 2 months. Although marked resolution of the previous abnormal findings was demonstrated, T2*-weighted grad...