Objectives: Early pharmacologic intervention is considered necessary for improving the prognosis in patients with first-episode schizophrenia (FES). However, few nationwide population-based studies have focused on early medication adherence. We investigated status of adherence to antipsychotics and effect later clinical outcomes FES.Methods: used data from South Korean Health Insurance Review A...

An interaction that gets things started he nuclear envelope clearly helps regulate eukaryotic DNA replication, but many of the molecular pieces of this process are still unknown. On page 177, Martins et al. describe a novel, direct interaction between the nuclear envelope and the genome, mediated by the inner nuclear membrane protein LAP2b and the nuclear matrix– associated protein HA95, that i...

Background Diagnostic studies using dynamic contrast enhanced (DCE) MRI perfusion imaging typically evaluate perfusion in terms of the myocardial perfusion reserve (MPR), which is the ratio of stress to rest myocardial blood flow (MBF) measurements. The aim of this study was to establish whether or not, in the case of absolute MBF quantitation, the MPR exhibits a diagnostic advantage over the s...

BACKGROUND Chronic lung disease of prematurity (CLDP) is a frequent complication of premature birth. Infants and children with CLDP are often prescribed complex medication regimens, which can be difficult for families to manage. OBJECTIVE We sought to determine whether non-adherence was associated with increased CLDP-related morbidities and to identify predictors of adherence. METHODS Recru...

BACKGROUND Many studies have investigated racial/ethnic disparities in medication non-adherence in patients with type 2 diabetes using common measures such as medication possession ratio (MPR) or gaps between refills. All these measures including MPR are quasi-continuous and bounded and their distribution is usually skewed. Analysis of such measures using traditional regression methods that mod...

An interaction that gets things started he nuclear envelope clearly helps regulate eukaryotic DNA replication, but many of the molecular pieces of this process are still unknown. On page 177, Martins et al. describe a novel, direct interaction between the nuclear envelope and the genome, mediated by the inner nuclear membrane protein LAP2b and the nuclear matrix– associated protein HA95, that i...