نتایج جستجو برای: mpk
تعداد نتایج: 187 فیلتر نتایج به سال:
How a committed cell can be reverted to an undifferentiated state is a central question in stem cell biology. This process, called dedifferentiation, is likely to be important for replacing stem cells as they age or get damaged. Tremendous progress has been made in understanding this fundamental process, but its mechanisms are poorly understood. Here we demonstrate that the aberrant activation ...
Azoles such as posaconazole (Posa) are highly potent against Trypanosoma cruzi . However, when tested in chronic Chagas disease patients, a high rate of relapse after Posa treatment was observed. It appears that inhibition T. cytochrome CYP51, the target azoles, does not deliver sterile cure monotherapy. Looking for suitable combination partners we have selected set inhibitors sterol and sphing...
Abstract The world is facing a global problem, namely Coronavirus (COVID 19). Covid-19 outbreak in Indonesia has spread to various regions. government imposed social distancing and several regions have Large-Scale Social Restrictions (PSBB) break the chain of spreading covid-19. Large-scale are restrictions on activities areas suspected being infected with prevent its spread. policy affects alm...
The 4 integrin, 4 7, plays an important role in recruiting circulating lymphocytes to the gastrointestinal tract, where its ligand mucosal addressin cell adhesion molecule-1 (MAdCAM-1) is preferentially expressed on high endothelial venules (HEVs). Dual antagonists of 4 1 and 4 7, N-(2,6-dichlorobenzoyl)-(L)-4-(2 ,6 -bis-methoxyphenyl)phenylalanine (TR14035) and N-{N-[(3,5-dichlorobenzene)sulfo...
Sex myoblast migration in the Caenorhabditis elegans hermaphrodite represents a simple, genetically amenable model system for studying how cell migration is regulated during development. Two separable components of sex myoblast guidance have been described: a gonad-independent mechanism sufficient for the initial anterior migration to the mid-body region, and a gonad-dependent mechanism require...
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