Transmissible spongiform encephalopathies (TSEs) or prion diseases are characterized by the accumulation in affected tissues of abnormal protein PrPTSE. We previously demonstrated PrPTSE blood macaques experimentally infected with variant Creutzfeldt–Jakob disease (vCJD), a human TSE, months to years prior clinical onset. That work supported prospect using as biomarker detect vCJD and possibly ...

Kidney Ankyrin Repeat-containing Proteins (KANKs) comprise a family of four evolutionary conserved proteins (KANK1 to 4) that localize the belt mature focal adhesions (FAs) where they regulate integrin-mediated adhesion, actomyosin contractility, and link FAs cortical microtubule stabilization complex (CMSC). The human KANK were first identified in kidney have been associated with cancer nephro...

Hind guts of 9i-day mouse embryos were transplanted into the posterior part of the coelomic cavity of 2|-day chick embryos. The hosts were sacrificed after 1-7 days and the mouse primordial germ cells (PGCs) in the graft and in the surrounding host tissues were searched for by means of the histochemical technique for alkaline phosphatase. Altogether 94 grafts were examined. During the first 3 d...

In previous publications, one of us demonstrated that variation in paramagnetic-ion contents is a major contributing factor to the different NMR relaxation times, T1 and T2, of water protons among normal mouse tissues; and between normal tissues and cancer cells. The nature of the paramagnetic ions involved was not determined. In the present communication, we report results of analysis of the c...