Few studies have investigated the effect of exercise on homocysteine and 15-F21-isoprostane in animal models. The present study was designed to examine the effect of long-term exercise and/ or high cholesterol diet on MDA, 15-F21-isoprostane and total homocysteine in the aorta and plasma of rabbits. Methods: 56 male rabbits were divided into four groups: normal diet (control), normal diet wi...

objective: gestational diabetes mellitus occurs during pregnancy is associated with increased cardiovascular risk. carotid intima media thickness (cimt) is a surrogate maker of subclinical atherosclerosis. the aim of this study is assessment of relationship between cimt and infra-renal abdominal aorta diameter in women with and without gestational diabetes mellitus. materials and methods: the c...

primary cardiac tumors are quite rare, especially in the pediatric age group, and their atypical presentations often prevent a timely diagnosis. most primary cardiac tumors in the pediatric age group are benign. fibromas are generally reported as the second most common primary cardiac tumors in the pediatric age group. these neoplasms are often intramural and involve the left ventricular free w...

Background Endothelial activation is one of the necessary initial steps in the formation of atherosclerotic plaque that facilitates immune cell recruitment and retention. To image and quantify early markers of endothelial inflammation, we recently developed a multiplexing peptide-based targeting system for post-formulation functionalization of perfluorocarbon (19F) nanoparticles (PFC NP) that i...

Introduction: Mouse models are increasingly used to investigate functional cardiovascular parameters. Pulse-wave velocity (PWV) is an important parameter for the evaluation of the arterial stiffness and cardiovascular risk. Several diseases such as hypertension and arteriosclerosis are associated with vascular remodeling and arterial stiffening. MRI methods have been used to quantify PWV in the...

aortic dissection occurs when a tear develops in the wall of the aorta, which is rare in the young population. this fatal disorder is hard to diagnose, especially in young patients. we present the case of aortic dissection in a 15-year-old boy referred to the emergency department of yazd university of medical sciences in november 2015. the patient presented to our department with sudden acute c...

During ontogeny, hematopoietic stem cells (HSC) become committed outside of hematopoietic organs. Once held to emerge from the yolk sac, they are currently thought to originate from the early aorta. However we now show that the allantois in the avian embryo and the placenta in the mouse embryo produce HSC in very large numbers. These sites thus appear to have a central role in the process of HS...

La patología de la aorta supone un reto para medicina. Tanto a nivel diagnóstico, como terapéutico, el volumen variables implicado ha hecho que dicha sea abordada por una ingente cantidad especialistas. En este documento, consensuado entre los grupos trabajo Aorta las sociedades españolas Anestesiología (SEDAR) y Cirugía Torácica-cardiovascular (SECTCV) se busca difundir modos más consensuados ...

CD41 expression is associated with the earliest stages of mouse hematopoiesis. It is notably expressed on some cells of the intra-aortic hematopoietic clusters, an area where the first adult-repopulating hematopoietic stem cells (HSCs) are generated. Although it is generally accepted that CD41 expression marks the onset of primitive/definitive hematopoiesis, there are few published data concern...

Primary cilia are microtubule-based structures present on most mammalian cells that are important for intercellular signaling. Cilia are present on a subset of endothelial cells where they project into the vessel lumen and are implicated as mechanical sensors of blood flow. To test the in vivo role of endothelial cilia, we conditionally deleted Ift88, a gene required for ciliogenesis, in endoth...