Medicinal chemistry depends on many other disciplines ranging from organic chemistry andpharmacology to computational chemistry. Typically medicinal chemists use the moststraightforward ways to prepare compounds. The validation of any design project comes from thebiological testing.Studies of the binding site of vinblastine by a single cross—linking experiment identified it asbeing between resi...

Este artículo presenta la evaluación de influencia altitud sobre el nivel del mar y longitud cadena aisladores en aislamiento eléctrico una línea transmisión 500 kV. Se simularon calcularon los sobrevoltajes tipo maniobra atmosférico o rayo mediante método Montecarlo para establecer probabilidad falla alto voltaje. desarrolló rutina MATLAB, donde se calcula grafica función densidad sobrevoltaje...

The recoil proton energy response has been measured by exposing cylindrical cells, filled with BC501A BICRON liquid scintillator, to mono-energetic neutron reference fields. We determine the required calibration parameters and report the detailed procedures for the experimental data handling. A dedicated Montecarlo simulation has successfully been used to check the consistency of the experiment...

We review some analytic results on the deconfinement transition in pure lattice gauge theories. In particular we discuss the relationship between the deconfinement transition in the (d + 1)-dimensional SU(2) model and the magnetization transition in the d-dimensional Ising model. This analysis leads to a precise estimate of the deconfinement temperature which agrees well with that obtained with...

GLAST Large Area Telescope (LAT) is a gamma ray telescope instrumented with silicon-strip detector planes and sheets of converter, followed by a calorimeter (CAL) and surrounded by an anticoincidence system (ACD). This instrument is sensitive to gamma rays in the energy range between 20 MeV and 300 GeV. At present, the first towers have been integrated and pre-launch data taking with cosmic ray...

In this paper, we use neural networks in order to model the seasonal component of the residual variance of a mean-reverting Ornstein-Uhlenbeck temperature process, with seasonality in the level and volatility. We also use wavelet analysis to identify the seasonality component in the temperature process as well as in the volatility of the temperature anomalies. Our model is validated on more tha...

In this work, effects of the anchor nodes geometry on the positioning error are evaluated for a least squares estimation (LSE) of the linearized multilateration problem. It is shown that for different node topologies, the choice of the cost function has a significant impact on the variance and bias of the averaged position error. The importance of knowledge of the range error model is discussed...

PT.PTM as one of major oil and gas company in Indonesia contributes highly to fulfilling demand Indonesia. However, with more than 40 years operation, PT. PTM is currently at its declining phase. Aggressive development projects have been planned sustain production. The latest project M-X new field developments. This Final Project intended assess the feasibility terms economic considering possib...