Epilepsy is a common neurological disease characterized by recurrent, usually unprovoked seizures due to excessive discharge of cerebral neurons. Medical therapy is the standard treatment for the majority of epilepsy patients. New antiepileptic drugs (AED), vigabatrin (VGB) and tiagabine (TGB) among others, have entered the market in recent years as a result of rational drug development. VGB an...

how to cite this article: asadi-pooya aa, emami m. effects of antiepileptic drugs on electroencephalographic findings inpatients with idiopathic generalized epilepsy. iranian journal of child neurology 2011;5(4):33-36. objective several antiepileptic drugs (aeds) such as phenobarbital (pb), carbamazepine (cbz), and valproate (vpa) may suppress interictal epileptiform activity. we investigated t...

BACKGROUND Patients with pulmonary arterial hypertension (PAH) are managed according to evidence-based treatment guidelines. METHODS AND RESULTS In this single-centre retrospective analysis, we examined outcomes of patients with PAH caused by congenital heart disease (PAH-CHD) with respect to exercise capacity and survival of adults treated with either bosentan or sildenafil monotherapy or bo...

Cefepime monotherapy was compared with cefepime-plus-amikacin dual therapy for treatment of febrile neutropenic patients. Response rates were significantly lower for patients receiving monotherapy who had neutrophil counts of <500 cells/mm3 but did not differ significantly between patients receiving dual therapy who had neutrophil counts of > or =500 cells/mm3 or <500 cells/mm3. Dual therapy is...

This study aimed to compare the efficacy and safety of rituximab (RTX) plus recombinant human thrombopoietin (rhTPO) with RTX alone in patients with immune thrombocytopenia (ITP) who had failed to respond to corticosteroids or relapsed. Recruited patients were randomized at a ratio of 2:1 into 2 groups: the combination group (RTX + rhTPO, n = 77) and the monotherapy group (RTX, n = 38). Overall...

OBJECTIVE To assess the risk of major congenital malformations (MCMs) in association with maternal use of valproic acid (VPA) in monotherapy or adjunctive therapy, and its relationship with dose. METHODS The analysis was based on prospectively acquired data from EURAP, a registry enrolling women treated with antiepileptic drugs (AEDs) in early pregnancy, in which the primary outcome is presen...