Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a promising target for anticancer therapy due to its ability counter the effects topoisomerase (Top1) poison, such as topotecan, thus, decreasing their efficacy. Compounds containing adamantane and monoterpenoid residues connected via 1,2,4-triazole or 1,3,4-thiadiazole linkers were synthesized tested against Tdp1. All derivatives exhibited inhibition a...

The first total synthesis of marine-derived penicimonoterpene (±)-1 has been achieved in four steps from 6-methylhept-5-en-2-one using a Reformatsky reaction as the key step to construct the basic carbon skeleton. A total of 24 new derivatives of 1 have also been designed and synthesized. Their structures were characterized by analysis of their 1H NMR, 13C NMR and HRESIMS data. Some of them sho...

The aim of the study was to determine aroma profiles four kinds Slovak honey (sunflower, honeydew, acacia, and linden) by a qualitative quantitative screening their volatile compounds gas chromatography for potential use in aromachology business sphere. results showed that several unique volatiles were identified one kind honey, while they not remaining ones. acacia had linalool oxide (1.13–3.9...

Snake fruit (Salacca zalacca (Gaert.) Voss) is a species traditionally cultivated in Indonesia and other Southeast Asian countries. The edible parts of the fruits contain certain amount total phenolic, flavonoid, monoterpenoid compounds, proving them to be their perfect sources. main goal this work was detect, quantify, identify various phenolic compounds present snake pulp. Ultrahigh performan...

BACKGROUND The phenolic monoterpenoid carvacrol, which is found in many plant essential oils (thyme, oregano and Alaska yellow cedar), is highly active against pest arthropods, but its mechanisms of action are not fully understood. Here, carvacrol is shown to bind in a membrane preparation containing insect nicotinic acetylcholine receptors (nAChRs). [(14) C]-Nicotine binding assays with Musca ...

Terpinen-4-ol (4TRP) is a monoterpenoid alcoholic component of essential oils obtained from several aromatic plants. We investigated the psychopharmacological and electrophysiological activities of 4TRP in male Swiss mice and Wistar rats. 4TRP was administered intraperitoneally (i.p.) at doses of 25 to 200 mg/kg and intracerebroventricularly (i.c.v.) at concentrations of 10, 20, and 40 ng/2 μL....

This study explored the antifungal potential of perillyl alcohol (PA), a natural monoterpene alcohol, against most prevalent human fungal pathogen C. albicans, its clinical isolates and four non-albicans species of Candida. To resolve the potential mechanisms, we used whole genome transcriptome analyses of PA treated Candida cells to examine the affected cellular circuitry of this pathogen. The...