نتایج جستجو برای: monosomy x

تعداد نتایج: 624158  

Journal: :Blood 1996
M R Baer S H Bernstein V L Brunetto K Heinonen K Mrózek V L Swann H Minderman A W Block L A Pixley N P Christiansen J W Fay M Barcos Y Rustum G P Herzig C D Bloomfield

Hematopoietic growth factors are being administered to patients with acute myeloid leukemia (AML) both to shorten the duration of chemotherapy-induced neutropenia and in an attempt to increase cytotoxicity of cell cycle-specific agents. However, limited information is available concerning the effects of growth factors in AML patients. To examine the in vivo effects of recombinant human granuloc...

Journal: :Acta medica Okayama 1989
K Kikkawa K Narahara H Kimoto

We performed a cytogenetic study on 140 nonpolymalformed patients with mental retardation of clinically undefined origin, using a high resolution banding technique, to determine how much chromosome abnormalities contribute to the etiology of this condition. A total of 15 patients (10.7%) were found to have autosomal or sex chromosomal abnormalities. Autosomal abnormalities included partial mono...

2011
Anna-Mia Johansson Anders Allgardsson Per Stenberg Jan Larsson

In Drosophila, the global increase in transcription from the male X chromosome to compensate for its monosomy is mediated by the male-specific lethal (MSL) complex consisting of five proteins and two non-coding RNAs, roX1 and roX2. After an initial sequence-dependent recognition by the MSL complex of 150-300 high affinity sites, the spread to the majority of the X-linked genes depends on local ...

Journal: :Atlas of Genetics and Cytogenetics in Oncology and Haematology 2011

Journal: :Neuropsychologia 2000
D V Bishop E Canning K Elgar E Morris P A Jacobs D H Skuse

X-monosomy is a form of Turner syndrome (TS) in which an entire X chromosome is missing. It is usually assumed that neuropsychological deficits in females with TS result from insufficient dosage of gene products from alleles on the sex chromosomes. If so, then parental origin of the single X chromosome should be immaterial. However, if there are imprinted genes on the X chromosome affecting bra...

Journal: :Journal of Medical Genetics 1992

Journal: :Hereditas 2009

Journal: :Blood 2009
Haydar Frangoul Tatsuki Koyama Jennifer Domm

marker because of reported hypermethylation in childhood MDS.3 Our patient initially showed 55.4% CALCA methylation in the peripheral blood, which decreased to 4.5% before the eighth cycle of AC. Importantly, reduction in methylation was not only due to clearance of malignant cells, but was evident in the clone itself.4 Before the third cycle, 58% of cells still carried monosomy 7, but complete...

Journal: :Archives of ophthalmology 2009
Bertil Damato Sarah E Coupland

OBJECTIVE To report our experience in translating uveal melanoma cytogenetics to routine clinical practice. METHODS In 1998, we confirmed that monosomy 3 in uveal melanomas correlates with mortality. In 1999, we started offering all patients treated by enucleation or local resection the possibility of monosomy 3 testing, using fluorescence in situ hybridization. In 2006, we started analyzing ...

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