BACKGROUND Previous experimental studies have shown that downstream microvascular thromboinflammation is involved in brain damage from acute ischemic stroke. Using intravital microscopy, we investigated and characterized the sequence of downstream microvascular thromboinflammation in an ischemia/reperfusion acute ischemic stroke model. METHODS AND RESULTS Rats underwent transient monofilament...

Copyright © 2016 Massachusetts Medical Society. A 65-year-old woman with a 5-year history of type 2 diabetes (a recent hemoglobin A1C level was 9.5%) reports the recent onset of burning, tingling, and stabbing pain in her feet that is worse at night and interferes with sleep and activities of daily living. Her medications include 500 mg of metformin and 2 mg of glimepiride, each taken twice dai...

Uncounted, and usually unobserved, numbers of pinnipeds find themselves entangled in lost fishing gear, monofilament line, nets, rope, plastic packaging in the ocean or on the shoreline. These animals may carry debris wrapped around themselves for long periods, and often die as a result, sometimes from deep chronic wounds. The pinniped species most affected by this modern and manmade phenomenon...

OBJECTIVES The aim of this study is to investigate whether quantitative sensory testing with Von Frey monofilaments (VFMs) can be used for the quantification of allodynia in patients with chronic neuropathic pain, and how the pain threshold of affected skin differs from healthy skin. METHODS Using VFMs, we aimed to determine the pain threshold in 22 patients suffering from allodynia as a cons...

In the global effort to eradicate dracunculiasis (guinea-worm disease) one of the main tools is the use of filters for filtering unsafe drinking-water. The expensive and high-quality monofilament nylon filters, which for many years were donated to all dracunculiasis-endemic countries, are now mainly reserved for highly endemic countries. Polyester cloth is less expensive, and we investigated th...

Females prefer dominant males as mating partners in numerous species. Male dominance rank is considered as an honest signal of male quality, because only healthy males in good condition are thought to be able to win fights with other males. Here, we tested whether activation of the immune system influences the success of males in male-male competition and mating in the field cricket, Gryllus in...

BACKGROUND To report the clinical experience and success rate with Ritleng intubation system in patients with congenital nasolacrimal duct obstruction. METHODS Twenty-four patients (32 eyes) with congenital nasolacrimal duct obstruction treated with the Ritleng intubation system were enrolled in this study. The mean age was 20.1+/-9.6 months. The technique involved introduction of a Prolene m...

BACKGROUND Neuropathic pain, caused by a lesion or a disease affecting the somatosensory system, is one of the most common complications in diabetic patients. The purpose of this study is to identify genetic factors contributing to this type of pain in a general diabetic population. METHOD We accessed the Genetics of Diabetes Audit and Research Tayside (GoDARTS) datasets that contain prescrip...

OBJECTIVE To evaluate the effect of case management by a clinical pharmacist on glycemic control and preventive measures in patients with type 2 diabetes mellitus. STUDY DESIGN Randomized controlled trial in a university-affiliated primary care internal medicine clinic. METHODS We recruited 80 patients with poorly controlled type 2 diabetes mellitus. A clinical pharmacist provided evaluatio...

PURPOSE The aim of the study was to investigate the prevalence of peripheral diabetic neuropathy (PDN) and associated characteristics among type 2 diabetic mellitus (DM2) patients in Passo Fundo, a city on Southern Brazil. BASIC PROCEDURES A cross-sectional study was conducted with 340 patients with type 2 diabetes mellitus. Tests were performed to evaluate vibration (tuning fork), light touc...