Several modified versions of the Monod model have been proposed to simulate algal dynamics in lakes by keeping the parent model’s advantages of simplicity and low data requirement. This study evaluated the performance of a widely-used modified Monod model in predicting algal dynamics at various time scales in Lake Tai, a typical shallow lake in east China, using multiple time series. Chlorophyl...

The observation has been made repeatedly that the induced synthesis of many different enzymes can be inhibited by a wide variety of carbohydrates (Benzer, 1953; Cohn, 1957, 1958; Epps and Gale, 1942; Gale, 1943; Happold and Hoyle, 1936; Herzenberg, 1958; Monod, 1941, 1947, 1956; Monod and Cohn, 1952; Neidhardt and Magasanik, 1956). One of the most characteristic and potent of these carbohydrate...

In recent years, there has been significant interest in yeast-based wastewater treatment due to its high pollutant removal rate and ability perform non-sterile environments. this work, a kinetic model was developed predict yeast growth substrate consumption during treatment. To determine the biological constants for use models, unique approach is presented. Candida utilis cultivated synthetic w...

Philosophy. Present address, Department of Biology, University of California, San Diego. 1 Sypherd, P. S., N. Strauss, and H. P. Treffers, Biochem. Biophys. Res. Comm., 7, 477 (1962). 2 Spiegelman, S., H. 0. Halvorson, and R. Ben-Ishi, in Amino Acid Metabolism (Baltimore: Johns Hopkins Press, 1955), pp. 124-170. 3Torriani, A.-M., Biochem. Biophys. Acta, 19, 224 (1956). 4Kameyama, T., and G. D. ...

Large differences in enzymatic activity are often found between intact cells and extracts. Lacking a better explanation, it has frequently been assumed that the penetration of the substrate is the rate limiting step in the intact cells. The experiments reported here were designed to test several hypotheses which might account for the discrepancy. The 3-galactosidase (lactase) in Escherichia col...

We have investigated the gating kinetics of calcium channels in the ATr5 cell line at the level of single channels and whole cell currents, in the absence and presence of dihydropyridine (DHP) calcium channel agonists. Although latencies to first opening and macroscopic currents are strongly voltage dependent, analysis of amplitude histograms indicates that the primary open-closed transition is...

The paper that introduced biochemists to the idea of allosteric feedback inhibition [Monod J, Changeux J-P & Jacob F (1963) J Mol Biol 6, 306-329] is now 50 years old, and the two papers on models for enzyme cooperativity that followed it [Monod J, Wyman J & Changeux J-P (1965) J Mol Biol 12, 88-118; Koshland DE, Némethy G & Filmer D (1966) Biochemistry 5, 365-385] are almost as old. All of the...

The Ca 2 1 -dependent gating mechanism of large-conductance calcium-activated K 1 (BK) channels from cultured rat skeletal muscle was examined from low (4 m M) to high (1,024 m M) intracellular concentrations of calcium (Ca 2 1 i ) using single-channel recording. Open probability ( P o ) increased with increasing Ca 2 1 i ( K 0.5 11.2 6 0.3 m M at 1 30 mV, Hill coefficient of 3.5 6 0.3), reachi...