With a view to applications in bifunctional catalysis, a modular cross-coupling strategy has been used to prepare amine bis(imidazolium) salts (3a and 3b) and an amine mono(imidazolium) salt (6) as precursors to chelating amido-NHC ligands. Treating the pro-ligands 3 with 3 equivalents of the bulky base KHMDS and Pd(OAc)(2) or PtCl(2)(COD) gave the four amido bis(N-heterocyclic carbene) pincer ...

Carbachol-stimulated accumulation of labeled IP4 or of total Ins 1,3,4,5-P4 in rat brain cortical slices was maximal in buffer containing 10 mM K+. Iso-osmotic elevation of extracellular K+ to 30 mM did not affect total Ins 1,3,4,5-P4 accumulation but did enhance carbachol stimulated Ins 1,4,5-P3 accumulation. Iso-osmotically elevated K+ suppressed carbachol stimulated accumulation of labeled I...

Dicopper species have been identified as the active sites in converting methane to methanol in Cu-zeolites. To understand the formation of these copper cores in mordenite, we used in situ time-resolved X-ray absorption spectroscopy during heat treatment. Significant dehydration enabled the reduction of the copper cores, after which molecular oxygen was cleaved. The activated oxygen bridged two ...

Rare-earth complexes are attractive catalyst systems due to their low cost, low toxicity and high reactivity. Modular ligand sets are ideal for complex formation since the steric and electronic properties of the resultant metal complexes can be easily varied. This thesis explores the structure and reactivity of new yttrium amidate complexes, which combine the highly reactive metal with the modu...

Convenient syntheses of mono- and bis-imidazolium 1,3,5-triazine derivatives bearing piperidine and morpholine substituents are reported. In situ deprotonation of the mono-imidazolium salts and reaction with Ag2O or Au(tht)Cl (tht = tetrahydrothiophene) precursors affords the corresponding Ag(NHC)Cl and Au(NHC)Cl carbene complexes. In the presence of Ag(I) or Au(I) salts the bis-imidazolium pin...

A series of b-cyclodextrin (b-CD) derivatives modified by L-cystine, including 3,30-L-cystine-bridged bis(b-CD) (2), 3-Lcystine-b-CD (3), 6,60-L-cystine-bridged bis(b-CD) (4) and 6-L-cystine-b-CD (5), were synthesised inmoderate yields by the reaction of L-cystine with mono-[2-O-(p-tolysulfonyl)]-b-CD (2-O-Ts-b-CD) or mono-[6-O-(p-tolysulfonyl)]-b-CD (6-OTs-b-CD). Their binding manners and incl...

The synthesis, spectroscopic characterisation and biological evaluation of mono- and bis-1,8-naphthalimide-conjugated ruthenium(ii)-polypyridyl complexes is presented. Spectroscopic DNA titrations, together with denaturation studies, show strong binding of both species to DNA through the naphthalimide arms. Linear and circular dichroism (LD and CD) spectroscopy reveal close association of the R...

The application of detailed structural data bases has now culminated in the successful design of a new generation of bisanthracyclines that form ultratight DNA complexes [Chaires, J. B., Leng, F., Przewloka, T., Fokt, I., Ling, Y. H., Perez-Soler, R., & Priebe, W. (1997) J. Med. Chem. 40, 261-266]. Daunomycin dimers were designed to bind to DNA in complexes resembling those of monomers intercal...

The cover picture represents the fascinating interaction between novel sugar-bridged fullerene dumbbells and [10]cycloparaphenylene nanoring. It visually depicts formation of mono- bis-pseudorotaxanes, which exhibit variations depending on sugar moiety anchoring strategy employed. Additionally, artwork highlights methano-dumbbell oligomers, emphasizing their potential application in sustainable...

The synthesis of the first series of 4-mono and 3,5-bis(dimethylamino)methyl-functionalized triarylphosphanes of the general formula PPh3 nArn (Ar = 1-C6H3(CH2NMe2)2-3,5 (NC(H)N), n = 1 (ligand 2) or n = 3 (ligand 4); Ar = 1-C6H4(CH2NMe2)-4 (NC(H)), n = 3 (ligand 7)) is described. These phosphanes were used for the construction of complexes of the form [AuCl(P)] and [PtCl2(P)2]. In these comple...