Streptococcus pneumoniae is increasingly drug resistant in recent years and becoming potential threat health hazard. The availability of the complete genomes of the virulent strains paves ways to combat the disease with pharmacoinformatics approaches. Transposase is an enzyme that catalyzes the movement of the transposon to another part of the genome, and helps the organism to develop antibioti...

This study was performed to find the selective chemical features for Aurora kinase-B inhibitors using the potent methods like Hip-Hop, virtual screening, homology modeling, molecular dynamics and docking. The best hypothesis, Hypo1 was validated toward a wide range of test set containing the selective inhibitors of Aurora kinase-B. Homology modeling and molecular dynamics studies were carried o...

abstract: cryptosporidium parvum is an apicomplexan protozoan parasite which causes diarrhea in both human and wide range of animals. since this protozoa causes remarkable economic losses in cattke industry in iran, the molecular determination of porotozoa and characterization of its protein pattern and immunogenic antigend are the aim of this study. in this study, diarheatic fecal samples of c...

background and purpose: by using advanced detection/identification methods, the list of emerging uncommon opportunistic yeast infections is rapidly expanding worldwide. our aim in the present study was sequence-based species delineation of previously unidentified yeasts obtained from a clinically yeast collection. materials and methods: a total of twenty three out of the 855 (5.7%) yeast isolat...

background and objectives: molecular epidemiology tools are widely used in determining epidemiology of tuberculosis. spoligotyping is a molecular epidemiology method that is used for characterization and typing of mycobacterium tuberculosis complex strains. the method is based on polymorphism of the chromosomal dr locus consisting of identical 36-bp drs alternating with 35-41 unique spacers. th...

objective(s): the nosocomial infections by aspergillus species are associated with constructions and increased dust loads in hospital indoors. our main object was to find the environmental sources of aspergillus species causing hospital acquired infections. materials and methods: the clinical and environmental samplings were performed during 18 months from spring 2010 to summer 2011 in imam edu...

background systemic candidiasis is a major public health concern. in particular, in immunocompromised people, such as patients with neutropenia, patients with acquired immune deficiency syndrome (aids) and cancer who are undergoing antiballistic chemotherapy or bone marrow transplants, and people with diabetes. since the clinical signs and symptoms are nonspecific, early diagnosis is often diff...

background: cholecystitis is one of the major digestive diseases. its prevalence is particularly high in some populations. significant risk factors associated with cholecystitis include age, sex, obesity, diet, parity and type 2 diabetes. objective: to determine the association between hla-drb1 and cholecystitis. methods: this casecontrol study included forty iraqi arab patients who had cholecy...