Nine evidence-based guidelines were identified that recommend the use of conventional synthetic disease-modifying antirheumatic drugs as a first-line therapy for patients with rheumatoid arthritis prior to using biologic or Janus kinase inhibitors.
 Methotrexate monotherapy was most commonly recommended drug by included guidelines.
 Eight combination multiple if is ineffective ...

background: bone mineral density (bmd) changes during the course of rheumatoid arthritis (ra). the present study was designed to investigate the status of bmd in patients with ra treated with anti-rheumatic drugs. methods: bmd at the femoral neck (fn-bmd) and lumbar spine (ls-bmd) were measured by dual energy x-ray absorptiometry (dxa) method using norland densitometer. disease activity (da) wa...