Lamellar bodies and alveolar lavage from adult mammalian lung contain unusually high concentrations of phosphatidylglycerol that could serve as a sensitive indicator of surfactant. Phosphatidylglycerol was absent and phosphatidylinositol was correspondingly prominent in surfactant from the preterm rabbit fetus. Phosphatidylglycerol rapidly appeared and phosphatidylinositol decreased following t...

The radiation modifying effect and toxicity of tetraethylthiuram disulfide (disulfiram) have been studied. Disulfiram (DSM) inhibits aldehyde dehydrogenase, dopamine-beta-oxygenase, microsomal mixed-function oxidases and cytochrome P-450 enzymes. It is widely used for aversion therapy in alcoholism. Disulfiram also inhibits tumor formation by several known carcinogens. A biphasic toxicity patte...

The influences of nanosilica and modified on cure, compression set, mechanical swelling characteristics are studied in blends ethylene-propylene-diene monomer (EPDM)/styrene-butadiene rubber (SBR). In EPDM/SBR composites, the made from rice husk ash (RHA) was utilised as a reinforcing nanofiller. interaction between matrix at interface is crucial for production composites. This study uses bis[3...

Hypertrophic cardiomyopathy (HCM) is a disease of mutant sarcomeric proteins (except for phenocopy). Cardiac hypertrophy is the clinical diagnostic hallmark of HCM and a major determinant of morbidity and mortality in various cardiovascular diseases. However, there is remarkable variability in expression of hypertrophy, even among HCM patients with identical causal mutations. We hypothesized mo...

effects of temperature and percentage of organic modifier were studied on retention and selectivity in rp-hplc using solvation parameter model. the system constants were determined by multiple linear regression analysis from experimental values in the retention factor for a group of different solutes with known descriptors by computer using the program spss/pc. the experimental results showed t...

It is well known that supercritical CO2 (SC-CO2) is very efficient to remove neutral lipids from a variety of matrices, such as plant seeds [1]. The valuable, polar phospholipids (PL) remain behind, which is ascribed to their limited solubility in SC-CO2 [2]. Typically, they are extracted by adding a polar modifier such as methanol or ethanol to the supercritical fluid (SC-fluid) [2-4]. In a re...

Isolated familial somatotropinoma (IFS) accounts for 18% of familial isolated pituitary adenoma (FIPA) cases. Recently, germline mutations of the aryl hydrocarbon receptor-interacting protein gene (AIP) have been found in families with pituitary adenoma predisposition, FIPA, and IFS. In this study, we investigate the AIP mutation status and perform a genome-wide scan to search for the modifier ...