One of the more recent associations of the murine H-2 major histocompatibility complex (MHC) with immune function has been the finding that cytotoxic T-effector cells generated by sensitization with viral-infected (1-6), chemically modified (7-9), or weak transplantation antigen-associated (10,11) syngeneic cells can efficiently lyse target cells which express the same viral, chemical, or weak ...

In this paper wave transformation in a submerged sloped breakwater and its hydraulic performance was simulated by developing a numerical model in Fortran. The code was established by combining porous flow and a two-phase model using VOF method. Modified Navier-Stokes and k-ε equations implemented to the model to simulate the flow in porous media. Cut cell method was modified to simulate...

The oxygen permeation performance of Ba0.5Sr0.5Co0.8Fe0.2O3−δ (BSCF) mixed-conducting multichannel hollow fiber (MCMHF) membranes was improved by surface modification via spin-spraying of a La0.6Sr0.4CoO3−δ (LSC) porous layer. At 1173 K, the oxygen permeation flux of the modified membranes was clearly enhanced and reached 9.68 mL·cm−2·min−1, which is a remarkable high value in the field of mixe...

The rapid increase in the number of genetically modified (GM) varieties has led to a demand for high-throughput methods to detect genetically modified organisms (GMOs). We describe a new dynamic array-based high throughput method to simultaneously detect 48 targets in 48 samples on a Fludigm system. The test targets included species-specific genes, common screening elements, most of the Chinese...

Two new 5-oxomilbemycins, 27-aldehyde-5-oxomilbemycin β12 (1) and 2-hydroxymilbemycin K (2), were isolated from a genetically engineered strain Streptomyces bingchenggensis BCJ60. Their structures were determined by comprehensive analyses of its 1 H and 13 C NMR, COSY, HMQC, and HMBC spectroscopic, HRESI-MS mass spectrometric and comparison with data from the literature. Preliminary studies sho...

Human telomerase is a ribonucleoprotein which uses its internal RNA moiety as a template for telomeric DNA synthesis. This enzyme is up-regulated in most malignant tumors and is therefore considered as a possible cancer target. Here we examined the effects of differently modified oligomers on telomeraseactivity from HL-60 cell extracts (TRAP-ezetrade mark assay). Phosphorothioate-modified oligo...

In this paper, we present a new type of PKC, system-oriented PKC,referred to as K(I)SOPKC that can be well adapted to a secure and a high speed communication between various systems and organizations of the present day network society. K(I)SOPKC is constructed on the basis of K(XIV)SE(1)PKC, a modified version of K(XII)SE(1)PKC [1], K(XIII)SE(1)PKC [2] and Kp(XIII)SE(1)PKC [2].

Kinetic analysis with mathematical models has become increasingly important to quantify physiological parameters in computed tomography (CT), positron emission tomography (PET), and dynamic contrast-enhanced MRI (DCE-MRI). The modified Kety/Tofts model and the graphical (Patlak) model have been widely applied to DCE-MRI results in disease processes such as cancer, inflammation, and ischemia. In...