Aims. The time evolution of the electromagnetic emission from blazars, in particular high frequency peaked sources (HBLs), displays irregular activity not yet understood. In this work we report a methodology capable of characterizing the time behavior of these variable objects. Methods. The Maximum Likelihood Blocks (MLBs) is a model-independent estimator which sub-divides the light curve into ...

Abstract Background Gastric cancer (GC) remains an important worldwide. Further understanding of the molecular mechanisms gastric carcinogenesis will enhance diagnosis and treatment GC. Methods The expression DLEU2 ETS2 was analyzed in several GC cell lines using GEPIA online analyze, qRT-PCR immunohistochemistry. biological behavior cells detected by CCK8, clone formation, transwell, wound hea...

The TeV and X-ray data obtained by the imaging Cherenkov telescope CAT and X-ray satellite BeppoSAX during the remarkable flare of Mkn 501 in April 16, 1997 are used to constrain the flux of the Cosmic Infrared Background (CIB) using different CIB models. We show that a non-negligible absorption of γ-rays due to the CIB could take place already in the low-energy (sub-TeV) domain of the spectrum...

Purpose: Despite the high prevalence of gastric cancer (GC), drug resistance is a major problem for effective chemotherapy. B7-H7 novel member B7 superfamily and expressed in most common cancers. However, role on aggressiveness GC chemosensitivity has remained unknown. Therefore, this study was designed to assess effect suppression using small interference RNA (siRNA) combination with docetaxel...

The BL Lac object Mkn 501, one of the only three extragalactic sources (with Mkn 421 and 1ES 2344+514) so far detected at TeV energies, was observed with the BeppoSAX satellite on 7, 11, and 16 April 1997 during a phase of high activity at TeV energies, as monitored with the Whipple, HEGRA and CAT Cherenkov telescopes. Over the whole 0.1-200 keV range the spectrum was exceptionally hard (α ≤ 1,...

OBJECTIVE Direct interaction with cancer-associated fibroblasts triggers WNT5A expression in human gastric carcinoma (GC) cells. In this study, we performed gene transduction experiments to investigate the significance of WNT5A in the GC tumor microenvironment. METHODS Gene transduction (pWNT5A and shWNT5A) was performed in human GC-derived MKN-7 cells. Altered gene expression was examined by...

Using the recent models of Malkan & Stecker (2001) for the infrared background radiation and extrapolating them into the optical and UV range using recent galaxy count data, we rederive the optical depth of the Universe to high energy γ-rays as a function of energy and redshift for energies betweeen 50 GeV and 100 TeV and redshifts between 0.03 and 0.3. We then use these results to derive the i...