نتایج جستجو برای: mitochondrial respiratory chain complex i

تعداد نتایج: 2265450  

Journal: :Journal of neurochemistry 2002
Anatoly A Starkov Brian M Polster Gary Fiskum

Abnormal accumulation of Ca2+ and exposure to pro-apoptotic proteins, such as Bax, is believed to stimulate mitochondrial generation of reactive oxygen species (ROS) and contribute to neural cell death during acute ischemic and traumatic brain injury, and in neurodegenerative diseases, e.g. Parkinson's disease. However, the mechanism by which Ca2+ or apoptotic proteins stimulate mitochondrial R...

Journal: :The Biochemical journal 1994
S Ray S Dutta J Halder M Ray

The effect of methylglyoxal on the oxygen consumption of Ehrlich-ascites-carcinoma (EAC)-cell mitochondria was tested by using different respiratory substrates, electron donors at different segments of the mitochondrial respiratory chain and site-specific inhibitors to identify the specific respiratory complex which might be involved in the inhibitory effect of methylglyoxal on the oxygen consu...

Journal: :Iranian Journal of Pediatrics 2022

: Mitochondrial diseases are caused by disturbances in the oxidative phosphorylation (OXPHOS) system. Leigh syndrome encompasses a spectrum of mitochondrial characterized necrotizing encephalopathy. Thus far, two cases carrying variant NDUFA9 with diagnosis have been reported. is subunit involved assembly and stability respiratory complex I. We present lethal phenotype four-month-old boy born t...

2015
Fernando N. Bralha Sanduni U. Liyanage Rose Hurren Xiaoming Wang Meong Hi Son Thomas A. Fung Francine B. Chingcuanco Aveline Y. W. Tung Ana C. Andreazza Pamela Psarianos Aaron D. Schimmer Leonardo Salmena Rebecca R. Laposa

Acute myeloid leukemia (AML) cells have high oxidative phosphorylation and mitochondrial mass and low respiratory chain spare reserve capacity. We reasoned that targeting the mitochondrial RNA polymerase (POLRMT), which indirectly controls oxidative phosphorylation, represents a therapeutic strategy for AML. POLRMT-knockdown OCI-AML2 cells exhibited decreased mitochondrial gene expression, decr...

2015
Daniel P. Lindsay Amadou K. S. Camara David F. Stowe Ryan Lubbe Mohammed Aldakkak

Excessive mitochondrial reactive oxygen species (ROS) emission is a critical component in the etiology of ischemic injury. Complex I and complex III of the electron transport chain are considered the primary sources of ROS emission during cardiac ischemia and reperfusion (IR) injury. Several factors modulate ischemic ROS emission, such as an increase in extra-matrix Ca(2+), a decrease in extra-...

Journal: :The Journal of neuroscience : the official journal of the Society for Neuroscience 2013
Amy Reeve Martin Meagher Nichola Lax Eve Simcox Philippa Hepplewhite Evelyn Jaros Doug Turnbull

Mitochondrial defects within substantia nigra (SN) neurons are implicated in the pathogenesis of Parkinson's disease. SN neurons show increased mitochondrial defects, mitochondrial DNA deletion levels, and susceptibility to such dysfunction, although the role of mitochondria in neuronal degeneration remains uncertain. In this study, we addressed this important question by exploring changes with...

2014
Edward T. Chouchani Carmen Methner Guido Buonincontri Chou-Hui Hu Angela Logan Stephen J. Sawiak Michael P. Murphy Thomas Krieg

Mitochondrial complex I, the primary entry point for electrons into the mitochondrial respiratory chain, is both critical for aerobic respiration and a major source of reactive oxygen species. In the heart, chronic dysfunction driving cardiomyopathy is frequently associated with decreased complex I activity, from both genetic and environmental causes. To examine the functional relationship betw...

Journal: :Biochimica et biophysica acta 1995
H A Bentlage A J Janssen A Chomyn G Attardi J E Walker H Schägger R C Sengers F J Trijbels

Antibodies have been raised against synthetic peptides corresponding to several computer-predicted epitopes of three mtDNA-encoded subunits, ND4, ND5 and ND6, of the human respiratory chain NADH dehydrogenase (Complex I). Antibodies were characterized by a sensitive immunoblotting assay using proteins from human skeletal muscle mitochondria and by immunoprecipitation of radio-labeled HeLa cell ...

2014
Yang Xue Qingqing Chen Tingting Ding Jiao Sun

The liver has been shown to be a primary target organ for SiO2 nanoparticles in vivo, and may be highly susceptible to damage by these nanoparticles. However, until now, research focusing on the potential toxic effects of SiO2 nanoparticles on mitochondria-associated energy metabolism in hepatocytes has been lacking. In this work, SiO2 nanoparticles 20 nm in diameter were evaluated for their ab...

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