Coupled cellular respiration requires that ATP and ADP be efficiently exchanged between the cytosol and the mitochondrial matrix. When growth factors are withdrawn from dependent cells, metabolism is disrupted by a defect in ATP/ADP exchange across the mitochondrial membranes. Unexpectedly, we find that this defect results from loss of outer mitochondrial membrane permeability to metabolic anio...

In a PTFE tape phase-vanishing reaction (PV-PTFE), a delivery tube sealed with PTFE tape is inserted into a vessel which contains the substrate. The reagent diffuses across the PTFE tape barrier into the reaction vessel. PTFE co-polymer films have been found to exhibit selective permeability towards organic compounds, which was affected by the presence of solvents. In this study, we attempted t...

ANGIOTENSIN II (ANG II), acting on AT1 receptors, results in a variety of physiological effects, such as vasoconstriction, tubular sodium retention, and increased arterial blood pressure (4, 5). Interestingly, increased ANG II signaling also results in increased urinary protein leakage. The increased protein leakage across the glomerular filtration barrier has classically been attributed to the...

Salvia miltorrhiza Bunge is a traditional Chinese medicine and has long been used for treating liver and heart diseases in China. Salvianic acid A is the main active component of Salvia miltorrhiza Bunge. In the present study, the ability of salvianic acid A in scavenging free radicals, inhibiting lipid peroxidation and mitochondrial membrane permeability transition, as well as respiration and ...

Clinical use of nonsteroidal anti-inflammatory drugs (NSAIDs) like diclofenac (DCLF) is limited by multiple adverse effects, including renal toxicity leading to acute kidney injury. In mice with DCLF-induced nephrotoxicity, TDZD-8, a selective glycogen synthase kinase (GSK)3β inhibitor, improved acute kidney dysfunction and ameliorated tubular necrosis and apoptosis associated with induced cort...

The permeabilization of the mitochondrial outer membrane by Bax and Bak during apoptosis is considered a key step and a point of no return in the signalling pathway. It is always closely related to the reorganization of mitochondrial cristae that frees cytochrome c to the intermembrane space and to massive mitochondrial fragmentation mediated by the dynamin-like protein Drp1. Despite multiple e...

This article discusses the influence of compressive shock waves on the permeability of cementitious materials. Shock waves are generated in water by Pulsed Arc Electrohydraulic Discharges (PAED). The practical aim is to increase the intrinsic permeability of the specimens. The maximum pressure amplitude of the shock wave is 250 MPa. It generates damage in the specimens and the evolution of dama...

Recent studies using small bowel endoscopy revealed that non-steroidal anti-inflammatory drugs including low-dose aspirin, can often induce small bowel injury. Non-steroidal anti-inflammatory drugs-induced small bowel mucosal injury involves various factors such as enterobacteria, cytokines, and bile. Experimental studies demonstrate that both mitochondrial disorders and inhibition of cyclooxyg...

Recent advances in cellular materials for active thermal management applications involve the integral design of their porous structure. In this work, open-cell aluminum foams with porosities range 0.60–0.76 are developed, containing pores spherical geometry and a bimodal pore size distribution. The fabrication strategy involves use replication method by infiltration liquid preforms formed packi...

Ban, Yuriko, and Lawrence J. Rizzolo. Differential regulation of tight junction permeability during development of the retinal pigment epithelium. Am J Physiol Cell Physiol 279: C744–C750, 2000.—The retinal pigment epithelium (RPE) is an epithelial region of the blood-brain barrier. During embryogenesis, permeability of the barrier gradually decreases. A culture model of RPE development reveale...