The random mismatch of semiconductor devices caused by local variations of the production process strongly influences critical performance parameters of analog circuits. In order to estimate the influence of the device mismatch on the circuit yield during the design phase, statistical mismatch models for the individual components must be provided for circuit simulation. Based on extensive stati...

Time reversal (TR) is the process of generating a spatio-temporal focus at a probe source (PS) location by transmitting a time-reversed version of a received signal. While TR focusing requires the PS for a coherent acoustic focus at its origin, the requirement of the PS has been partially relaxed by the introduction of the concept of a virtual source array (VSA) (J. Acoust. Soc. Am. 2009, 125, ...

Main cause of restenosis after balloon angioplasty is due to the stresses generated in the artery as well as from the stent artery interaction. Understanding the factors that are involved in this interaction, and the ability to evaluate the stresses that are formed in the artery, could help to lessen the number of failures. The goal of the present study is to develop computationally efficient n...

The minimum apparent diffusion coefficient (ADCmin) derived from diffusion-weighted MRI (DW-MRI) and the maximum standardized uptake value (SUVmax) of FDG-PET are markers of aggressiveness in lung cancer. The numeric correlation of the two parameters has been extensively studied, but their spatial interplay is not well understood. After FDG-PET and DW-MRI coregistration, values and location of ...

The signal integrity of the circuit, as one of the important design issues in high-speed digital system, is usually seriously affected by the signal reflection due to impedance mismatch in the DDR3 bus. In this paper, a novel optimization method is proposed to optimize impedance mismatch and reduce the signal reflection. Specifically, by applying the via parasitic, an equivalent model of DDR3 h...

Gene conversion, non-reciprocal transfer from one homologous sequence to another, is a major force in evolutionary dynamics, promoting co-evolution in gene families and maintaining similarities between repeated genes. However, the properties of the transfer - where it initiates, how far it proceeds and how the resulting conversion tracts are affected by mismatch repair - are not well understood...

Main cause of restenosis after balloon angioplasty is due to the stresses generated in the artery as well as from the stent artery interaction. Understanding the factors that are involved in this interaction, and the ability to evaluate the stresses that are formed in the artery, could help to lessen the number of failures. The goal of the present study is to develop computationally efficient n...

The sequencing of the genomes of a variety of species and the growing databases containing expressed sequence tags (ESTs) and complementary DNAs (cDNAs) facilitate the design of highly specific oligomers for use as genomic markers, PCR primers, or DNA oligo microarrays. The first step in evaluating the specificity of short oligomers of about twenty units in length is to determine the frequencie...

This paper reports reconstitution of 5'-nick-directed mismatch repair using purified human proteins. The reconstituted system includes MutSalpha or MutSbeta, MutLalpha, RPA, EXO1, HMGB1, PCNA, RFC, polymerase delta, and ligase I. In this system, MutSbeta plays a limited role in repair of base-base mismatches, but it processes insertion/deletion mispairs much more efficiently than MutSalpha, whi...

We have shown previously that human leukocyte antigen (HLA) immunogenicity, defined by the physiochemical properties of mismatched amino acids, predicts humoral alloimmunity, and now report the effect on long-term graft survival after kidney transplantation. The influence of HLA-A and -B mismatch, number of amino acid mismatches (after interlocus subtraction) and their physiochemical (electrost...