نتایج جستجو برای: mirna target genes

تعداد نتایج: 793481  

2015
Dongli He Qiong Wang Kun Wang Pingfang Yang Zhi Min Yang

The first 24 hours after imbibition (HAI) is pivotal for rice seed germination, during which embryo cells switch from a quiescent state to a metabolically active state rapidly. MicroRNAs (miRNAs) have increasingly been shown to play important roles in rice development. Nevertheless, limited knowledge about miRNA regulation has been obtained in the early stages of rice seed germination. In this ...

Journal: :Development 2009
Liang Zhang Molly Hammell Brian A Kudlow Victor Ambros Min Han

Although microRNA (miRNA)-mediated functions have been implicated in many aspects of animal development, the majority of miRNA::mRNA regulatory interactions remain to be characterized experimentally. We used an AIN/GW182 protein immunoprecipitation approach to systematically analyze miRNA::mRNA interactions during C. elegans development. We characterized the composition of miRNAs in functional ...

Journal: :Fishes 2022

Visceral white nodules disease (VWND), caused by Pseudomonas plecoglossicida, is a common among cage-farmed large yellow croaker (Larimichthys crocea) in China. However, comprehensive investigations of the molecular defensive mechanisms used L. crocea response to P. plecoglossicida infection remain relatively rare. Here, we constructed transcriptomes spleen at 12 h and 24 after challenge. We id...

2017
Lingyu Meng Cuicui Liu Jinhui Lü Qian Zhao Shengqiong Deng Guangxue Wang Jing Qiao Chuyi Zhang Lixiao Zhen Ying Lu Wenshu Li Yuzhen Zhang Richard G Pestell Huiming Fan Yi-Han Chen Zhongmin Liu Zuoren Yu

MicroRNAs (miRNAs) loss-of-function phenotypes are mainly induced by chemically modified antisense oligonucleotides. Here we develop an alternative inhibitor for miRNAs, termed 'small RNA zipper'. It is designed to connect miRNA molecules end to end, forming a DNA-RNA duplex through a complementary interaction with high affinity, high specificity and high stability. Two miRNAs, miR-221 and miR-...

Journal: :PLoS Biology 2004
Bino John Anton J Enright Alexei Aravin Thomas Tuschl Chris Sander Debora S Marks

MicroRNAs (miRNAs) interact with target mRNAs at specific sites to induce cleavage of the message or inhibit translation. The specific function of most mammalian miRNAs is unknown. We have predicted target sites on the 3' untranslated regions of human gene transcripts for all currently known 218 mammalian miRNAs to facilitate focused experiments. We report about 2,000 human genes with miRNA tar...

2016
Jinsong Wei Jiafeng Wang Yulan Zhou Shouquan Yan Keshen Li Hongsheng Lin

MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surger...

Journal: :Cancer discovery 2015
George M Yousef

A recent study identified genetic variations within the miRNA response elements of miRNA target genes (miRSNP) that can affect the base paring between miRNAs and their targets, and hence alter miRNA-target interactions. The authors also undertook functional validation studies and were able to demonstrate that overexpression of miR-3162-5p resulted in a 20% decrease in expression of the KLK3 rs1...

Journal: :Journal of dairy science 2010
A Zidi M Amills A Tomás O Vidal O Ramírez J Carrizosa B Urrutia J M Serradilla A Clop

The main goal of the current work was to identify single nucleotide polymorphisms (SNP) that might create or disrupt microRNA (miRNA) target sites in the caprine casein genes. The 3' untranslated regions of the goat alpha(S1)-, alpha(S2)-, beta-, and kappa-casein genes (CSN1S1, CSN1S2, CSN2, and CSN3, respectively) were resequenced in 25 individuals of the Murciano-Granadina, Cashmere, Canarian...

Journal: :Cold Spring Harbor symposia on quantitative biology 2006
K Chen N Rajewsky

microRNAs (miRNAs) are a class of small noncoding RNAs that posttranscriptionally regulate a large fraction of genes in animal genomes. We have previously published computational miRNA target predictions in five vertebrates, six flies, and three nematodes. Here, we report a comprehensive study of the "deep" conservation of miRNA targets and conserved 3'UTR (untranslated region) motifs in genera...

Journal: :Neoplasia 2009
Johan H Gibcus Lu Ping Tan Geert Harms Rikst Nynke Schakel Debora de Jong Tjasso Blokzijl Peter Möller Sibrand Poppema Bart-Jan Kroesen Anke van den Berg

Hodgkin lymphoma (HL) is derived from preapoptotic germinal center B cells, although a general loss of B cell phenotype is noted. Using quantitative reverse transcription-polymerase chain reaction and miRNA microarray, we determined the microRNA (miRNA) profile of HL and compared this with the profile of a panel of B-cell non-Hodgkin lymphomas. The two methods showed a strong correlation for th...

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