نتایج جستجو برای: mir 182 5p

تعداد نتایج: 56569  

2016
Olivier E Pardo Leandro Castellano Catriona E Munro Yili Hu Francesco Mauri Jonathan Krell Romain Lara Filipa G Pinho Thameenah Choudhury Adam E Frampton Loredana Pellegrino Dmitry Pshezhetskiy Yulan Wang Jonathan Waxman Michael J Seckl Justin Stebbing

Here, we show that miR-515-5p inhibits cancer cell migration and metastasis. RNA-seq analyses of both oestrogen receptor receptor-positive and receptor-negative breast cancer cells overexpressing miR-515-5p reveal down-regulation of NRAS, FZD4, CDC42BPA, PIK3C2B and MARK4 mRNAs. We demonstrate that miR-515-5p inhibits MARK4 directly 3' UTR interaction and that MARK4 knock-down mimics the effect...

2017
Feng Fang Tianqiang Song Ti Zhang Yunlong Cui Gewen Zhang Qingqing Xiong

MicroRNAs (miRNAs) play critical roles in hepatocellular carcinoma (HCC) progression and are key determinants of prognosis. In this study, we found that miR-425-5p was elevated in HCC and correlated with poor prognostic clinicopathological features and low post-operative long-term survival. Multivariate survival analysis indicated that miR-425-5p expression was an independent risk factor for ov...

2016
Chengxia Liu Ming Li Yingbin Hu Ning Shi Haisheng Yu Haiyan Liu Haifeng Lian

Increasing evidence suggests that microRNAs are associated with many important biologic processes in carcinogenesis. Despite ample research revealing the dysregualtion of miR-486-5p in various cancers, little is known about the roles of miR-486-5p in colorectal carcinoma (CRC). In this study, we investigated the biological functions and molecular mechanisms of miR-486-5p in CRC growth and invas...

2017
Xin Zhang Zhi-Hua Ye Hai-Wei Liang Fang-Hui Ren Ping Li Yi-Wu Dang Gang Chen

Our previous research has demonstrated that miR-146a-5p is down-regulated in hepatocellular carcinoma (HCC) and might play a tumor-suppressive role. In this study, we sought to validate the decreased expression with a larger cohort and to explore potential molecular mechanisms. GEO and TCGA databases were used to gather miR-146a-5p expression data in HCC, which included 762 HCC and 454 noncance...

2015
Nalini Venkatesan Perinkulam Ravi Deepa Vikas Khetan Subramanian Krishnakumar

PURPOSE Retinoblastoma (RB), a primary pediatric intraocular tumor, arises from primitive retinal layers. Several novel molecular strategies are being developed for the clinical management of RB. miRNAs are known to regulate cancer-relevant biological processes. Here, the role of selected miRNAs, namely, miR-532-5p and miR-486-3p, has been analyzed for potential therapeutic targeting in RB. M...

Journal: :Diabetes care 2014
Francisco J Ortega Josep M Mercader José María Moreno-Navarrete Oscar Rovira Ester Guerra Eduardo Esteve Gemma Xifra Cristina Martínez Wifredo Ricart Jennifer Rieusset Sophie Rome Monika Karczewska-Kupczewska Marek Straczkowski José Manuel Fernández-Real

OBJECTIVE This study sought to identify the profile of circulating microRNAs (miRNAs) in type 2 diabetes (T2D) and its response to changes in insulin sensitivity. RESEARCH DESIGN AND METHODS The circulating miRNA profile was assessed in a pilot study of 12 men: 6 with normal glucose tolerance (NGT) and 6 T2D patients. The association of 10 circulating miRNAs with T2D was cross-sectionally val...

2018
Te-Fu Tsai Ji-Fan Lin Kuang-Yu Chou Yi-Chia Lin Hung-En Chen Thomas I-Sheng Hwang

Introduction miR-99a-5p, known to play an important role in mammalian target of rapamycin (mTOR) regulation, is downregulated in human bladder cancer. The study aimed to investigate the anticancer activity of miR-99a-5p and the possible mechanism associated with mTOR in bladder cancer cells. Materials and methods Vectors expressing miR-99a-5p were transfected into human urinary bladder urothe...

2015
Giovanni Lugli Aaron M. Cohen David A. Bennett Raj C. Shah Christopher J. Fields Alvaro G. Hernandez Neil R. Smalheiser Baohong Zhang

To assess the value of exosomal miRNAs as biomarkers for Alzheimer disease (AD), the expression of microRNAs was measured in a plasma fraction enriched in exosomes by differential centrifugation, using Illumina deep sequencing. Samples from 35 persons with a clinical diagnosis of AD dementia were compared to 35 age and sex matched controls. Although these samples contained less than 0.1 microgr...

Journal: :Oncology reports 2013
Yifeng Sun Bo Su Peng Zhang Huikang Xie Hui Zheng Yongjie Xu Qiaoling Du Huan Zeng Xiao Zhou Chang Chen Wen Gao

The present study investigated the expression of miR-150 and miR-3940-5p in non-small cell lung carcinoma (NSCLC) and its relationship with clinicopathologic features. Samples included tumor, tumor-adjacent and normal lung parenchyma tissues from 90 NSCLC patients and 17 cases of embryonic lung cDNA. The expression levels of miR-150, miR-18b-5p, m...

2015
Yang Sun Tingting Zhang Cuiping Wang Xianglan Jin Congwei Jia Shuangni Yu Jie Chen

BACKGROUND Aberrant microRNA (miRNA) expression is associated with tumor development. This study aimed to elucidate the role of miR-615-5p in the development of pancreatic ductal adenocarcinoma (PDAC). METHODS Locked nucleic acid in situ hybridization (LNA-ISH) was performed to compare miR-615-5p expression in patients between PDAC and matched adjacent normal tissues. Effects of miR-615-5p ov...

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