Objective(s): Impairment of nerve cells of brain induced by hypoxia results in energy-deprivation and dysfunction, which accompanies with neurons apoptosis. Improving function of nerve cells is important for treating cerebral anoxia. This study aimed to investigate the role of Quercetin (Quer) in hypoxia-induced injury of pheochromocytoma (PC-12) cells. Materials and Methods: PC-12 cells were c...

Background: MiR-103a-3p is a small non-coding RNA and has been reported to be involved in osteogenic proliferation and differentiation, but the role of miR-103a-3p in human osteoarthritis (OA) remains unclear. Objectives: In this study, we aimed to explore its function and molecular target in chondrocytes during OA pathogenesis. Materials an...

Background: Due to the estrogen participation in modulating the proliferation and commitment of stem cells and the effects of miR-21 and miR-155 expression on reduced proliferation and colony formation of acute myeloid leukemia (AML), the aim of the present study was to evaluate the effect of estradiol on expression of miR-21 and miR-155 in the NB4 cell line, as an acute promyelocytic leukemia ...

MicroRNAs are abundant small non-coding RNA with a variety of known functions, including transcriptional activation and inhibition. Recent evidence has suggested that microRNA expression may influence the responsiveness some cancers to chemotherapy, liver lung cancers. Some now specific microRNAs, such as miR-21, miR-155, miR-375, oral cancer chemotherapy – although much remains be discovered. ...

Background: The identification of miRNAs that play a role in the regulation viral life cycle and its related liver illness opens door to development diagnostic biomarkers can categorize patients at higher risk for developing end-stage disease. This study was designed investigate hepatitis-induced chronic disease (CLD) Egyptian population, as well their potential possible hepatitis virus infecti...

objective(s):an earlier meta-analysis on gene expression data derived from four microarray, two cdna library, and one sage experiment had identified rgs5 as one of only ten non-housekeeping genes that were reported to be expressed in human trabecular meshwork (tm) cells by all studies. rgs5 encodes regulator of g-protein signaling-5. the tm tissue is the route of aqueous fluid outflow, and is r...

objective(s): erythropoiesis is regulated by some extrinsic and intrinsic factors as micrornas (mirnas). mirnas are endogenously small non-coding regulatory rnas which play vital roles in the variety of cellular fate, critical processes; growth, apoptosis, metabolism, survival of the cells and specially differentiation. several mirnas such as mir-16 and mir-451 have been shown to be correlated ...

background: microrna (mirna) is small endogenous, single strand rna molecules that regulate gene expression at post-transcriptional level through several mechanisms to affect key cellular event including male germ cells differentiation, proliferation, development and apoptosis. mutation and/or aberrant expression of mirnas have been associated with progression of various disorders, including in...