By J. F. HOFFMAN, I. J. WOLMAN, ,J. FIILLIER AND A. K. PAIuPART T HE ULTHASTRUCTURE of the isolated plasmssa nsemssbramses (ghosts) from nornsal hunsans erythrocytes has beers directly studied by Hillier ansd iloffmams5 umsimig the electrons mssicroscope. Thse reproducibility of the methods ensployed has beets further evaluated ansd the observationss extensded to the membramses of erythrocytes ...

which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Hematological malignancies complicating β-thalassemia syndromes: a single center experience TO THE EDITOR: Only few reports have addressed the occurrence of hematological malignancies in patients suffering from β-thalassemia. We herein report two patients wi...

BACKGROUND AND AIM Both thalassemia and carnitine deficiency represent independent causes of erythropoietin resistance, and thus anemia, in uremic patients. We evaluated the unknown long-term effects of L-carnitine administration in β-thalassemic on chronic hemodialysis. METHODS We studied twelve subjects (M = 8; F = 4) affected by β-thalassemia minor (β-thal; HbA2 level = 6.6 ± 0.6%) and for...

BACKGROUND There are various clinical symptoms of thalassemia intermedia, and they lie roughly between those of major and minor forms of the disease. Patients with thalassemia intermedia occasionally require blood transfusions. This renders them susceptible to pulmonary arterial hypertension (PAH) syndrome, which is one of the most significant complications in patients with thalassemia intermed...

Based upon the lack of clinical samples available for research in many laboratories worldwide, a significant gap exists between basic and clinical studies of beta-thalassemia major. To bridge this gap, we developed an artificially engineered model for human beta thalassemia by knocking down beta-globin gene and protein expression in cultured CD34+ cells obtained from healthy adults. Lentiviral-...

OBJECTIVE Different indices and formulas of CBC parameters have been suggested as indicators of early stage screenings to detect couples with β-thalassemia minor (BTMi). In this study, we evaluated the accuracy of five previous published formulas and compared them to our new formula (│80-MCV│×│27-MCH│) in screening of β-thalassemia. METHODS All couples in the premarital β-thalassemia screenin...

Introduction: One of the complications anesthesia that can be encountered in thalassemia patients is cardiovascular instability caused by chronic anemia, cardiomyopathy, and endocrinopathy. In addition, with preeclampsia may also experience postoperative risks such as sustained hypertension, stroke, venous thromboembolism, seizures. This case report will discuss anesthetic management pregnant w...