نتایج جستجو برای: minimuminhibitory concentration

تعداد نتایج: 381026  

2016

Cultivating Awareness and Resilience in Education (CARE for Teachers) is a mindfulness-based professional development program designed to reduce stress and improve teachers’ performance and classroom learning environments. A randomized controlled trial examined program efficacy and acceptability among a sample of 50 teachers randomly assigned to CARE or waitlist control condition. Participants ...

Journal: :Journal of Chemical Education 1953

Journal: :Journal of the ACM 2015

Journal: :Bioorganic & medicinal chemistry letters 2005
Ian R Hardcastle Shafiq U Ahmed Helen Atkins A Hilary Calvert Nicola J Curtin Gillian Farnie Bernard T Golding Roger J Griffin Sabrina Guyenne Claire Hutton Per Källblad Stuart J Kemp Martin S Kitching David R Newell Stefano Norbedo Julian S Northen Rebecca J Reid K Saravanan Henriëtte M G Willems John Lunec

A series of 2-N-alkyl-3-aryl-3-alkoxyisoindolinones has been synthesised and evaluated as inhibitors of the MDM2-p53 interaction. The most potent compound, 3-(4-chlorophenyl)-3-(4-hydroxy-3,5-dimethoxybenzyloxy)-2-propyl-2,3-dihydroisoindol-1-one (NU8231), exhibited an IC50 of 5.3 +/- 0.9 microM in an ELISA assay, and induced p53-dependent gene transcription in a dose-dependent manner, in the S...

Journal: :Journal of clinical psychology 2009
Shauna L Shapiro

As the field of psychology continues to expand and evolve, one fruitful avenue of exploration has been the integration of mindfulness into psychological theory and practice. Mindfulness is defined as the awareness that arises out of intentionally attending in an open and discerning way to whatever is arising in the present moment. Two decades of empirical research have generated considerable ev...

Journal: :ISPRS Int. J. Geo-Information 2016
Lucy W. Mburu Mohamed Bakillah

It is generally acknowledged that the urban environment presents different types of risk factors, but how the structural effects of areas influence the risk levels in neighboring areas has been less widely investigated. This research assesses the local effects of burglary contributory factors on burglary over small areas in a large metropolitan region. A comparative framework is developed for a...

Journal: :Molecules 2016
Gonzalo Vera Carlos F Lagos Sebastián Almendras Dan Hebel Francisco Flores Gissella Valle-Corvalán C David Pessoa-Mahana Jaime Mella-Raipán Rodrigo Montecinos Gonzalo Recabarren-Gajardo

Based on a known pharmacophore model for 5-HT₆ receptor antagonists, a series of novel extended derivatives of the N-arylsulfonyindole scaffold were designed and identified as a new class of 5-HT₆ receptor modulators. Eight of the compounds exhibited moderate to high binding affinities and displayed antagonist profile in 5-HT₆ receptor functional assays. Compounds 2-(4-(2-methoxyphenyl)piperazi...

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