Milk thistle extract is one of the most commonly used nontraditional therapies, particularly in Germany. Milk thistle is known to contain a number of flavonolignans. We evaluated the effect of silymarin, on the activity of various hepatic drug-metabolizing enzymes in human hepatocyte cultures. Treatment with silymarin (0.1 and 0.25 mM) significantly reduced the activity of CYP3A4 enzyme (by 50 ...

The milk thistle plant is one of the famous plants that have been gaining popularity for its therapeutic potential centuries. Milk seed oil (MTSO) has subjected to extensive research. fixed was extracted from seeds Silybum marianum (L.) using petroleum ether as a solvent by soxhlet device. GC-MS used identify chemical composition oil. antioxidant activity MTSO tested ABTS method, which showed a...

Our objective was to create a calibration model for rapid determination of the oil in whole Milk Thistle seeds using the method Fourier Transform Near Infrared (FT-NIR) Spectroscopy. The seeds from different distributors and dealers from several European countries and from the harvests 2010, 2011 and 2013 were processed by Soxhlet extraction in Det-Gras N instrument and its FTNIR spectra were c...

Use of herbal drugs in the treatment of liver diseases has a long tradition, especially in Eastern medicine. Standardization has been a problem, and randomized, placebo-controlled clinical trials to support efficacy are lacking. Some herbal extracts promoted for gastrointestinal or biliary disorders contain potent hepatotoxic alkaloids and are harmful. However, some of these extracts have yield...

Since the beginning of evaluation plants in terms human health, bioactivity properties have been studied laboratory and thus standards brought to treatment methods with plants. For this purpose, some bioactive component analyzes 18 herbal capsules 2 liquid syrups produced by Naturin Company were performed our current study. In context, total oxidant antioxidant status these plant mixtures evalu...

Despite increasing recognition of potential untoward interactions between herbal products and conventional medications, a standard system for prospective assessment of these interactions remains elusive. This information gap was addressed by evaluating the drug interaction liability of the model herbal product milk thistle (Silybum marianum) with the CYP3A probe substrate midazolam. The inhibit...

Seven pure flavonolignans were isolated from an extract of milk thistle [Silybum marianum (L.) Gaertn (Asteraceae)], by semipreparative reverse-phase HPLC, and identified based on spectroscopic and LC-MS=IT-TOF data. All seven compounds were screened as potential antitumor-promoting agents by using the in vitro short-term 12-O-tetradecanoylphorbol-13-acetate (TPA)induced Epstein-Barr virus earl...