Metal-based nanomaterials with shifting or mixed redox states have been widely applied for combating against bacteria-infected diseases by virtue of their peroxidase (POD)-like catalytic activity. Herein, a polyoxometalate-based heterojunction (GdP5W30@WS2) (W6+/W5+) is devised to achieve boosted reactive oxygen species (ROS) generation near-infrared (NIR) laser-facilitated W6+/W5+ cycling acce...

Perioperative hypothermia is a common and serious complication of anesthesia and surgery and is associated with many adverse perioperative outcomes. It prolongs the duration of action of inhaled and intravenous anesthetics as well as the duration of action of neuromuscular drugs. Mild core hypothermia increases thermal discomfort, and is associated with delayed post anaesthetic recovery. Mild h...

Roels, H. A., Buchet, J. P., Lauwerys, R. R., and Sonnet, J. (1975). British JournalofIndustrial Medicine, 32, 181-192. Comparison of in vivo effect of inorganic lead and cadmium on glutathione reductase system and 8-aminolevulinate dehydratase in human erythrocytes. The activity of 8-aminolevulinate dehydratase (ALAD) of erythrocytes, the lead (Pb-B) and cadmium (Cd-B) concentration in whole b...

Colon cancer (CC) is accepted as the third type of that causes death in world. Oxidative stress and low glutathione peroxidase (GPx) activity can cause CC. This study aims to show whether GPx Oxidized (GSSG)/ reduced (GSH) levels, which are considered oxidative markers, effective etiopathogenesis Erythrocyte isolation was performed 3 ml blood sample taken from volunteers aged 18-75 years. Hemog...

introduction: in  major b -thalassemia impaired biosynthesis of beta hemoglobin leads to accumulation of unpaired alpha hemoglobin chain. an iron overload generates oxygen-free radicals which ultimately leads to tissue injury. the aim of this investigation was to evaluate serum antioxidants in patients with major b -thalassemia and those with minor thalassemia in comparison with respective age ...

The glutathione peroxidase (GSH-Px)-like reduction of H2O2 by the selenoorganic compound 2-phenyl-1,2-benzoisoselenazol-3(H)-one (PZ51: Ebselen) was studied using glutathione (GSH) and the therapeutic agent N-acetylcysteine (NAC) to provide reducing equivalents. In a purely chemical system containing H2O2 and in an enzymatic system of glucose/glucose oxidase-generated H2O2 Ebselen alone did not...

Depletion of glutathione (GSH) by buthionine sulfoximine (BSO) has been reported to be toxic against some cancer cells and to sensitize many tumours including neuroblastoma (NB) to anticancer drugs. The balance between the production rate of reactive oxygen species (ROS) and the function of GSH affects the intracellular reduction-oxidation status, which is crucial for the regulation of several ...

Glutathione redox status is a commonly used oxidative stress biomarker. High-performance liquid chromatography-ultraviolet (HPLC-UV) and HPLC-electrochemical detection (HPLC-ECD) have been used to assess glutathione status but have potential limitations due to challenging sample preparation procedures or electrochemical signal degradation. Thus, this study aimed to validate an HPLC-ECD approach...