Osteoblast migration is significant in skeletal development. Recently, high mobility group box 1 protein (HMGB1) has been shown to highly expressed in cartilage to regulate endochondral ossification. Nevertheless, whether HMGB1 can modulate osteoblast proliferation and migration is poorly understood, as well as the intracellular signalling pathways that are involved in this process. Herein, we ...

The neuronal development of fetuses and infants is exquisitely sensitive to disruption by various environmental factors. Yet few chemicals in widespread use have been thoroughly tested for developmental neuro toxicity. Most such testing relies on animal studies, a laborious and costly process that is not always a good predictor of human health outcomes. A team of researchers now describes a fas...

The neuronal development of fetuses and infants is exquisitely sensitive to disruption by various environmental factors. Yet few chemicals in widespread use have been thoroughly tested for developmental neuro toxicity. Most such testing relies on animal studies, a laborious and costly process that is not always a good predictor of human health outcomes. A team of researchers now describes a fas...

Prostate cancer is a common worldwide health problem in males with a poor prognosis due in part to tumor invasion and migration. The crude extract of Euphorbia formosana (CEEF) has been used for the treatment of numerous diseases, however, its effects on the migration and invasion of prostate cancer cells have yet to be examined. In the present study, we investigated the effects of CEEF on the ...

BACKGROUND This study aimed to investigate the relationship between miR-506 and proliferation and migration of breast cancer cells. MATERIAL AND METHODS MiR-506 mimics, inhibitor, and negative control (NC) were transfected into MDA-MB-231 breast cancer cells. Cell proliferation, cell counting, colony formation assay, and Transwell assay were applied to evaluate the proliferation and migration...

Abstract Background Breast cancer (BC) is one of the commonest female cancers, which characterized with high incidence. Although treatments have been improved, prognosis BC patients in advanced stages remains unsatisfactory. Thus, exploration molecular mechanisms underneath progression necessary to find novel therapeutic methods. Frizzled class receptor 2 (FZD2) belongs family, has proven promo...

The aqueous extract of Psidium guajava budding leaves (PE) bears an extremely high content of polyphenolic and isoflavonoids. Whether it could be used as an anti-tumor chemopreventive in view of anti-angiogenesis and anti-migration, we performed the assay methods including the MTT assay to examine the cell viability; the ELISA assay to test the expressions of VEGF, IL-6 and IL-8; the western bl...

Photoactivated hypericin has a potent cytotoxic effect over a wide range of cells. However, very recently hypericin has been shown to have antitumoral and antimetastatic effects in the dark. The aim of this study was to test whether hypericin in the dark affects angiogenesis. Different in vitro assays were used to study the potential effects of this compound on key steps of angiogenesis, namely...

MicroRNA-204 (miR-204) has been reported to be frequently downregulated in various types of cancer, including renal, brain, ovary, hematological and colon cancer. The present study, investigated the effects of miR‑204 on renal cell carcinoma. Following transfection of miR‑204, an MTT assay, cell migration assay, cell invasion assay, western blot analysis and luciferase assay were performed in r...

Angiogenesis is important for invasive tumor growth and metastasis. Its inhibition is a promising tactic for limiting tumor progression. Here, we showed that Piezo2 knockdown led to decreased glioma angiogenesis and reduced vascular hyperpermeability. Piezo2 was highly expressed in tumor endothelial cells, and its knockdown suppressed vascular leakage and tumor angiogenesis. In a retinal vascul...