OBJECTIVE To determine whether smaller atrial shunts (large persistent foramen ovale (PFO) and small atrial septal defect (ASD)) are inherited and whether this has a role in the inheritance of migraine with aura. METHODS Contrast echocardiography was used to detect atrial shunts in 71 relatives of 20 probands with a significantly sized atrial shunt (large PFO or ASD). Four families with three...

See related article, pages 2438–2445. Migraine with aura has been consistently associated with increased risk of ischemic stroke.1–3 Most studies suggest that this association is particularly strong for younger women. Although several potential biological mechanisms have been proposed to explain the migraine-stroke association, the precise mechanisms remain unknown. Because migraine is particul...

OBJECTIVE The aim of the present study was to compare the analgesic efficacy of a single dose of sublingual piroxicam to that of a placebo during acute attacks of migraine without aura. METHODS The drug (N = 30) or a placebo (N = 30) was administered, on randomisation and double-blind basis, to 60 patients between 18 and 50 years of age suffering from migraine without aura. The patients were ...

" What do cortical thickness increases mean and what are the potential implications? " Migraine is a very widespread and debili-tating disease and according to the WHO, one of the most common disorders of the nervous system. Prevalence studies estimate that migraine affects 15–25% of women and 6–8% of men [1–4], and over 2.5 million people in North America have migraine at least one day per wee...

Objective: To determine whether smaller atrial shunts (large persistent foramen ovale (PFO) and small atrial septal defect (ASD)) are inherited and whether this has a role in the inheritance of migraine with aura. Methods: Contrast echocardiography was used to detect atrial shunts in 71 relatives of 20 probands with a significantly sized atrial shunt (large PFO or ASD). Four families with three...

M igraine is an episodic brain disorder [1] that affects about 15 percent of the population [2,3]. The disorder can be highly disabling [4], and has been estimated to be the most costly neurological disorder in the European Community, costing more than 27 billion per year [5]. Two clinical forms are commonly seen: migraine with aura and migraine without aura [6]. Aura in this context is defi ne...

OBJECTIVE To evaluate the association between migraine and cardiovascular disease, including stroke, myocardial infarction, and death due to cardiovascular disease. DESIGN Systematic review and meta-analysis. DATA SOURCES Electronic databases (PubMed, Embase, Cochrane Library) and reference lists of included studies and reviews published until January 2009. Selection criteria Case-control a...

Background: Association between Helicobacter pylori (HP) infection and migraine and the effect of HP eradication on relief of migraine headache have been studied but the results are controversial. Objectives: To evaluate the effect of HP eradication in treatment of patients affected by migraine. Materials and Methods: Eighty consecutive HP infected patients affected by migraine without au...

OBJECTIVE To assess the response of a patient with chronic migraines to a short program of chiropractic care (diversified technique). METHOD The study was run over a 13 week period with chiropractic spinal manipulative therapy (CSMT) on a once weekly schedule for 5 weeks, followed by an 8 week re-evaluation. OUTCOME MEASURES To measure the effect of treatment, a previously reported diary sy...