BACKGROUND AND PURPOSE Angiotensin II, through stimulation of AT(1) receptors, not only controls blood pressure but also modulates cerebrovascular flow. We sought to determine whether selective AT(1) antagonists could be therapeutically advantageous in brain ischemia during chronic hypertension. METHODS We pretreated spontaneously hypertensive rats (SHR) and normotensive Wistar-Kyoto controls...

While changes in blood velocity in the middle cerebral artery relative to rest were assessed by transcranial Doppler sonography, 70 volunteers with no sign of cerebrovascular disease performed two (left and right middle cerebral artery) series of six cognitive tasks. The tasks are assumed to be processed predominantly by either the left (verbal and mathematical tests performed aloud) or the rig...

Preeclampsia may affect severely the cerebral circulation leading to impairment of cerebral autoregulation, edema, and ischemia. It is not known whether impaired autoregulation occurs before the clinical onset of preeclampsia, and whether this can predict the occurrence of preeclampsia. Seventy-two women at 25 to 28 weeks of gestation were studied. Control values were derived from 26 nonpregnan...

A 34-year-old gravida was diagnosed with hydrops fetalis, hydrothorax with cardiac compression, hygroma, ascites, and subcutaneous edema at 20 weeks of gestation. The peak systolic umbilical artery and middle cerebral artery velocities were 30 cm/sec and 28 cm/sec, respectively. The umbilical vein demonstrated a lowamplitude blunted waveform. The cerebral venous sinuses were imaged by color Dop...

A computer linked Doppler system was used to make continuous measurements of cerebral blood flow velocity (CBFV) from the middle cerebral artery, mean arterial blood pressure (MAP) from the umbilical artery, and heart rate before, during, and for 20 minutes after the endotracheal administration of 200 mg/kg of porcine surfactant in 10 preterm infants with respiratory distress syndrome. Within t...

OBJECTIVE To explore middle cerebral artery (MCA) and anterior cerebral artery (ACA) blood flow responses to superimposed acute hypoxemia in growth-restricted fetuses with and without established brain-sparing flow during basal conditions. MATERIAL AND METHODS 47 term fetuses suspected of growth restriction were exposed to an oxytocin challenge test with simultaneous cardiotocography and Dopp...

Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...

AIM To study continuously cerebral blood flow velocity in the middle cerebral artery before, during, and after tube feeding in neonates. METHOD Cerebral blood flow velocity was measured in 14 neonates using a Doppler ultrasound device. Blood pressure, respiration, and oxygen saturation were monitored. RESULTS Mean blood flow velocity decreased from 37 cm/s before feeding to 33 cm/s (P < 0.0...