Emerging viral diseases are a major problem to human and veterinary public health and continue to be an eminent threat to the world economy. Fluorescent microsphere immunoassay (FMIA) can be used for the detection of emerging infectious diseases in humans and animals. FMIA is a novel molecular diagnostic technology for the detection of antibodies to at least 100 target antigens in a small sampl...

This paper presents an on-chip biosensor using a polystyrene fluorescent microsphere as an optical resonator to enhance the fluorescence emission. The microsphere is attached on the wall of a microchannel in a polydimethylsiloxane (PDMS) optofluidic chip and excited by a focused laser beam using a confocal Raman microscope system. Based on the shift of Whispering Gallery modes (WGMs), this sens...

Power-spectral-density measurements of any sampled signal are typically restricted by both acquisition rate and frequency response limitations of instruments, which can be particularly prohibitive for video-based measurements. We have developed a new method called intensity modulation spectral analysis that circumvents these limitations, dramatically extending the effective detection bandwidth....

We demonstrate scaffolding of plasmonic nanoparticles by topological defects induced by colloidal microspheres to match their surface boundary conditions with a uniform far-field alignment in a liquid crystal host. Displacing energetically costly liquid crystal regions of reduced order, anisotropic nanoparticles with concave or convex shapes not only stably localize in defects but also self-ori...

The bound state structure and dynamics for an atom trap formed from the whispering gallery modes ~WGMs! of a dielectric microsphere are investigated. The coupling of the quantized internal and external atomic degrees of freedom plays a fundamental role in the quantum dynamics of this atom gallery. The radiative processes for a cold atom near a microsphere are modified due to the special symmetr...

Thermal fluctuations, geometric exclusion, and external driving all govern the mechanical response of dense particulate suspensions. Here, we measure the stress-strain response of quasi-two-dimensional flow-stabilized microsphere heaps in a regime in which all three effects are present using a microfluidic device. We observe that the elastic modulus and the mean interparticle separation of the ...

Background. Experimental data demonstrate the persistence of a transmural vasodilator reserve in the face of depressed resting myocardial perfusion. The present study was designed to determine whether resting myocardial hypoperfusion indicates exhausted coronary reserve (CR). Methods and Results. Fifteen patients with stable angina, isolated left anterior descending coronary artery (LAD) stenos...

Experiments were performed to determine the effect of hematoporphyrin derivative (HPD) photodynamic therapy on blood flow to normal rat intestine. A segment of rat jejunum was exposed to red (greater than 590 nm) light (200 mW/cm2) 24 h after the i.v. administration of HPD. Blood flow to the light exposed segment was determined using the radioactive microsphere technique while blood flow to an ...

Ambient S annealing was adopted to regulate the crystallinity of a ZnS microsphere, which resulted in a significant improvement in the photocatalytic hydrogen production activity (PHPA). Moreover, with S ambient treatment, wurtzite ZnS showed better PHPA than sphalerite ZnS, possibly because the inter-polar electric field of the wurtzite phase could promote the separation of photo-excited elect...