objective: different signaling pathways have been identified that are involved in the cellular response to opiates. the mitogen-activated protein kinase pathway is one of the most important signaling pathways underlying the neuronal response to opiates. micrornas (mirnas) are considered to be post-transcriptional regulators of gene expression with paramount significance, which plays key roles i...

Sen CK. MicroRNAs as new maestro conducting the expanding symphony orchestra of regenerative and reparative medicine. Physiol Genomics 43: 517–520, 2011. First published April 5, 2011; doi:10.1152/physiolgenomics.00037.2011.— The human genome encodes 1,048 microRNAs (miRNAs). These miRNAs regulate virtually all biological processes. Leaving ignominy on the significance miRNAs behind we are appr...

The imprinted miR379-410 cluster contains 38 microRNAs (miRNAs) that are involved in diverse neurodevelopmental processes and are important regulators of neuronal function. The implications of these miRNAs in neurological diseases have been recently recognized.In the present minireview, the current findings regarding the brain-specific functions of miR379-410 cluster miRNAs are summarized and d...

RESULT We have developed miREval 2.0, an online tool that can simultaneously search up to 100 sequences for novel microRNAs (miRNAs) in multiple organisms. miREval 2.0 uses multiple published in silico approaches to detect miRNAs in sequences of interest. This tool can be used to discover miRNAs from DNA sequences or to validate candidates from sequencing data. AVAILABILITY http://mimirna.cen...

We recently reported an interesting finding that the Ebola virus (EBOV) encodes functional microRNAs (miRNAs) that can be produced through the host’s miRNA processing machinery. Furthermore, prediction of EBOV miRNA target genes provided some clues about the regulatory roles of EBOV miRNAs. In summary, our study paves the road for further investigating the roles of EBOV miRNAs in viral infectio...

MicroRNAs are plentiful in plants, as in animals. The effects of mutations which disrupt their processing imply that miRNAs have important roles in plant development. Although the targets of these miRNAs are still not known, excellent candidates have been identified based on sequence similarity to the miRNAs.

MicroRNAs (miRNAs) are a set of short (21-24 nt) noncoding RNAs that play significant regulatory roles in cells. In the past few years, research on miRNA-related problems has become a hot field of bioinformatics because of miRNAs' essential biological function. miRNA-related bioinformatics analysis is beneficial in several aspects, including the functions of miRNAs and other genes, the regulato...

Chemopreventive drugs including natural chemopreventive drugs and synthetic chemopreventive drugs, it not only can prevent cancer, can also play a role in tumor treatment. MicroRNAs (miRNAs) is a kind of short chains of non-coding RNA, regulating the expression of many genes through the way of degradation of mRNA or inhibitting mRNA translation. In recent years, more and more studies have shown...

Exosomes are secreted by all cell types and contain proteins and nucleic acids. Here, we report that breast cancer associated exosomes contain microRNAs (miRNAs) associated with the RISC-Loading Complex (RLC) and display cell-independent capacity to process precursor microRNAs (pre-miRNAs) into mature miRNAs. Pre-miRNAs, along with Dicer, AGO2, and TRBP, are present in exosomes of cancer cells....

MicroRNAs (miRNAs), highly conserved, short (approx. 22 nucleotides) non-coding RNAs, exhibit a fine-tune control over gene expression by complementary sequence binding and translational repression of protein coding mRNA transcripts. Recently, the role of miRNAs has been increasingly investigated in various physiological or pathophysiological events. Circulating platelets are crucial for coagul...