نتایج جستجو برای: microrna ها

تعداد نتایج: 378343  

Journal: :Genetics and molecular research : GMR 2015
C H Zhao G-C Cheng R L He Y Hong Q L Wan Z-Z Wang Z-Y Pan

The aim of this study was to investigate the expression level of microRNA-499 and its clinical significance in serum of patients with acute myocardial infarction (AMI). We recruited 59 patients with AMI and 60 healthy individuals undergoing physical examination in our hospital during the same period as controls. Peripheral blood was drawn in the morning on the same day of microRNA extraction. T...

2015
Reza Ghanbari Neda Mosakhani Jahanbakhsh Asadi Nazila Nouraee Seyed Javad Mowla Yaghoub Yazdani Ashraf Mohamadkhani Hossein Poustchi Sakari Knuutila Reza Malekzadeh

BACKGROUND Colorectal cancer is one of the most commonly diagnosed cancers and cancer- related death worldwide. Identification of new specific biomarkers could be helpful to detection of this malignancy. Altered plasma microRNA expression has been identified in many cancers, including colorectal cancer. OBJECTIVES The main objective of this study was to identify the circulating microRNAs with...

2017
Daria Liamina Wladimir Sibirnyj Anna Khokhlova Viacheslav Saenko Eugenia Rastorgueva Aleksandr Fomin Yury Saenko

In our study, we estimate an effect from chromosome aberrations and genome mutations on changes in microRNA expression profiles in cancer cell lines demonstrating different radiosensitivity. Here, cell viability and microRNA spectrum have been estimated 1, 4, and 24 h after irradiation. MiSeq high-throughput sequencing system (Illumina, San Diego, CA, USA) is employed to perform microRNA spectr...

2013
Haggi Mazeh Ido Mizrahi Nadia Ilyayev David Halle Björn LDM Brücher Anton Bilchik Mladjan Protic Martin Daumer Alexander Stojadinovic Itzhak Avital Aviram Nissan

The discovery of microRNA, a group of regulatory short RNA fragments, has added a new dimension to the diagnosis and management of neoplastic diseases. Differential expression of microRNA in a unique pattern in a wide range of tumor types enables researches to develop a microRNA-based assay for source identification of metastatic disease of unknown origin. This is just one example of many micro...

2016
Yun-Long Lu Jin-Guang Yao Xiao-Ying Huang Chao Wang Xue-Min Wu Qiang Xia Xi-Dai Long

Our recent investigation has shown that the variables of microRNA-1268a may involve in hepatocellular carcinoma (HCC) tumorigenesis. Here, we attempted to identify the prognostic significance of microRNA-1268a expression in tumor tissues by a retrospective analysis in 411 patients with HCC, and analyze its effects on post-operative adjuvant transarterial chemoembolization (TACE) improving HCC p...

2016
Zhiguang Pan Zhifeng Shi Hua Wei Fengyan Sun Jianping Song Yongyi Huang Te Liu Ying Mao

Glioma stem cells belong to a special subpopulation of glioma cells that are characterized by strong proliferation, invasion and drug resistance capabilities. Magnetic nanoparticles are nanoscale biological materials with magnetic properties. In this study, CD133(+) primary glioma stem cells were isolated from patients and cultured. Then, magnetic nanoparticles were used to mediate the transfec...

2016
Xavier Loyer Valérie Paradis Carole Hénique Anne-Clémence Vion Nathalie Colnot Coralie L Guerin Cécile Devue Sissi On Jérémy Scetbun Mélissa Romain Jean-Louis Paul Marc E Rothenberg Patrick Marcellin François Durand Pierre Bedossa Carina Prip-Buus Eric Baugé Bart Staels Chantal M Boulanger Alain Tedgui Pierre-Emmanuel Rautou

OBJECTIVE Previous studies suggested that microRNA-21 may be upregulated in the liver in non-alcoholic steatohepatitis (NASH), but its role in the development of this disease remains unknown. This study aimed to determine the role of microRNA-21 in NASH. DESIGN We inhibited or suppressed microRNA-21 in different mouse models of NASH: (a) low-density lipoprotein receptor-deficient (Ldlr-/-) mi...

2011
Anna Lena Datwyler Gisela Lättig-Tünnemann Wei Yang Wulf Paschen Sabrina Lin Lin Lee Ulrich Dirnagl Matthias Endres Christoph Harms

Small ubiquitin-like modifier (SUMO)2/3 but not SUMO1 conjugation is activated after transient cerebral ischemia. To investigate its function, we blocked neuronal SUMO2/3 translation through lentiviral microRNA delivery in primary cortical neurons. Viability was unaffected by SUMO2/3 silencing unless neurons were stressed by transient oxygen-glucose deprivation (OGD). Both 15 and 45 minutes of ...

2015
Adrian M. Gomez Diego Altomare Wei-Lun Sun Narasimha M. Midde Hao Ji Michael Shtutman Jill R. Turner Kim E. Creek Jun Zhu

BACKGROUND Environmental enrichment alters susceptibility in developing drug addiction. We have demonstrated that rats raised in an enriched condition are more sensitive than rats raised in an impoverished condition to nicotine-induced locomotor activity, and this is associated with alterations of phosphorylated extracellular signal-regulated kinase 1/2 within the prefrontal cortex. This study ...

ژورنال: :مجله دانشگاه علوم پزشکی زنجان 0
شیما مجتهدی sh mojtahedi محمد رضا کردی mr kordi مسعود سلیمانی m soleimani سید ابراهیم حسینی se hosseini

چکیده زمینه و هدف: فاکتورهای رونویسی و micrornas، خانواده های بزرگ در تعامل با هم و مولکول های تنظیم کننده ی ژن در ارگانیسم های چند سلولی هستند. هدف ما در این مطالعه بررسی اثر دویدن هوازی کوتاه مدت بر میزان بیان ژن re1-silencing transcription factor/neuron-restrictive silencer factor و microrna-124 در هیپوکمپ موش های صحرایی نر بالغ بود. روش بررسی: 12 سر موش صحرایی نر بالغ 8 هفته با میانگین وزنی...

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