The hot springs in certain areas of Ramsar contain (226)Ra and (222)Rn. The effects of natural radiation on the inhabitants of these areas and the inhabitant's radiosensitivity or adaptive responses were studied. One group of volunteers from areas with high natural background radiation and another group from areas with normal background radiation were chosen as the case and control group respec...

The insecticide Thimet 10-G was tested for mutagenic activity by 4 different genetic systems. It was unable to induce gene mutation in Salmonella, transfection inhibition in Mycobacterium, micronuclei formation in mice, and sister-chromatid exchange (SCE) in human lymphocytes were evaluated. It caused in mice an increase in the ratio of normochromatic to polychromatic erythrocytes and in human ...

Galindo, T.P.S.; Rosário, I.R.; da Silva, E.M.; E. (2014) Micronucleus test in frillfin goby Bathygobius soporator (Valenciennes, 1873) from tide pools of Salvador city, Brazil. Braz. J. Aquat. Sci. Technol. 18(1):19-24. eISSN 19839057. DOI: 10.14210/bjast.v18n1.p19-24 The genotoxic effects of metals were evaluated in Bathygobius soporator using the micronucleus test. The frequencies of micronu...

Objective: Micronuclei are induced in cells by a variety of substances, like UV radiation, infrared rays, X-radiations, and chemicals. Among them tobacco- specific nitrosamines have been reported to be potent mutagenic agents which are thought to be responsible for the induction of chromosomal aberrations resulting in production of micronuclei. The main aim of our study is to compare MN frequen...

Wilcoxon’s signed rank test is often inverted, using Walsh averages, to yield exact, distribution free, randomization based confidence intervals for a constant treatment effect or center of symmetry; however, many treatment effects are not constant, so that this interval is not applicable. This article proposes a new way to invert the signed rank test, again using Walsh averages, to produce an ...

BACKGROUND Lung cancer is the most common cancer in the world accounting for 17.6% cancers worldwide. The AAR i n I ndian population varies f r om 0.98-15.55. The aim of t he present study was to analyze areduction in neoadjuvant chemotherapy related acute toxicity in locally advanced lung cancer (stage IIIA and III B) using Wobe Mugos E and its evaluation using micronuclei as a cytogenetic mar...

To investigate interactions between hepatitis C virus (HCV) RNA replication complexes, a system was developed to simultaneously select different HCV subgenomic replicons within the same cell. Transcomplementation of defective replicons was not observed, suggesting an isolated and independent nature of the HCV RNA replication complex. In contrast, a high level of competition between replicons wa...

The induction of micronuclei was studied in mouse bone marrow treated or not with 5, 10 and 20 mg/kg b. wt. of Abana (a herbal preparation) before exposure to 0-3 Gy of γ-radiation. Whole-body irradiation of mice resulted in a dose-dependent increase in the frequency of micronuclei. Treatment of mice with various doses of Abana before exposure to different doses of γ-rays resulted in a signific...

Deficiency of autophagy has been linked to increase in nuclear instability, but the role of autophagy in regulating the formation and elimination of micronuclei, a diagnostic marker for genomic instability, is limited in mammalian cells. Utilizing immunostaining and subcellular fractionation, we found that either LC3-II or the phosphorylated Ulk1 localized in nuclei, and immunoprecipitation res...

The sensitivity of anuran to the effects habitat destruction and contamination has led a preoccupying global decline in their populations. Morphological biomarkers such as micronuclei other erythrocyte nuclear abnormalities (ENAs), well occurrence hepatic melanin, can be used evaluate impacts. In present study, these two parameters were combined for situ assessment soybean cultivation on grassf...