Supplementary Figure Legends Figure S1. Distribution and colocalization of expression of EphB1 and ephrinB2 with cells and primary afferents within the DH and DRG after TCI. A, EphB1 (green) with astrocytes (GFAP, red, left) and, in a small amount, with microglial cell (IBA, red, right). B, EphrinB2 (green) with astrocytes (red, left), but not microglial cell (red, right). C, D, EphrinB2 (green...

PURPOSE Microglia represent the primary resident immune cells in the CNS, and have been implicated in the pathology of neurodegenerative diseases. Under basal or "resting" conditions, microglia possess ramified morphologies and exhibit dynamic surveying movements in their processes. Despite the prominence of this phenomenon, the function and regulation of microglial morphology and dynamic behav...

microglia cells are a subset of central nervous system (cns) macrophages. changes in the cns such as injury, or developmental events, follow by morphological and physiological changes in microglia cells. in this study organotypic brain slice cultures under serum free condition were used to investigate the morphology and lectin histochemistry of microglia and macrophages in the cns in vitro. mic...

Superparamagnetic iron oxide nanoparticles (SPIO) are applied as contrast media for magnetic resonance imaging (MRI) and treatment of neurologic diseases despite the fact that important information concerning their local interactions is still lacking. Due to their small size, SPIO have great potential for magnetically labeling different cell populations, facilitating their MRI tracking in vivo....

ASTROCYTES MODULATE MICROGLIAL PHENOTYPE AND DENDRITIC CELL-LIKE PROPERTIES by Nischal K. Padala Microglia are the resident immune cells of the CNS. In the healthy CNS, they express negligible levels of MHC II molecules as well as co-stimulatory molecules CD40, CD80 and CD86 necessary for antigen presentation to and activation of T cells. Co-stimulatory molecule expression can be induced in iso...