PURPOSE The selective degeneration of pericytes and the proliferation of endothelial cells (ECs) appear to be associated with microaneurysm formation, an initial deficit in the early stage of diabetic retinopathy. The preventive effect of aldose reductase (AR) inhibitor (ARI) for high glucose-induced pericyte loss and EC growth was investigated. METHODS The effect of high glucose (30 mM) expo...

Diabetic retinopathy is a micro vascular complication which is characterized by several changes in the retina. Changes occur in the diameter of the blood vessel, microaneurysm, hemorrhage exudates, and the growth of new blood vessels. These changes need to be detected early so that steps for further handling and treatment can be determined. Laser therapy is one of the common therapies for patie...

Advances in medical device technology have resulted in a plethora of devices that sense, record, transform and process digital data. Images are a key form of diagnostic data, and many devices have been designed and deployed that capture high-resolution in-vivo images in different parts of the spectrum. Computers have enabled complex forms of reconstruction of cross-sectional/ 3D structure (and ...

Background and Purpose: Microaneurysms and fibrinoid necrosis of cerebral cortical arteries have been reported to be related to the pathogenesis of intracerebral hemorrhage associated with cerebral amyloid angiopathy. To elucidate the pathogenesis of such vascular lesions, we conducted the present study. Methods: Five hundred serial sections from brain tissue of a patient with severe amyloid an...

BACKGROUND AND PURPOSE CT angiography spot sign predicts hematoma expansion in patients with acute intracerebral hemorrhage (ICH). The spot sign may represent a site of active extravasation, a locus of arrested hemorrhage forming fibrin globes, or represent associated epiphenomena such as hypertensive microaneurysms. We sought to describe the evolution of spot signs over 60 seconds in acute ICH...

PURPOSE To characterize white dots in diabetic retinopathy (DR) and their association with disease severity using ultra-wide-field scanning laser ophthalmoscopy. METHODS We randomly selected 125 eyes of 77 patients (25 eyes from individual categories of the international classification of DR severity) for which ultrawide field photographs were obtained. We characterized white dots, which were...

Diabetes strikes when the pancreas stops to produce sufficient insulin, gradually disturbing the retina of the human eye, leading to diabetic retinopathy. The blood vessels in the retina become changed and have abnormality. Exudates are concealed, micro-aneurysms and haemorrhages occur in the retina of eye, which intern leads to blindness. The presence of these structures signifies the harshnes...

Purpose: To evaluate the efficacy of computer algorithms in the detection and grading of retinopathy derived from screening of diabetic photographs. Methods: Screening fundus photographs (5 per eye) taken with a mydriatic camera in a general ophthalmology clinic for 52 sequential diabetic patients were graded by a general ophthalmologist and a retina specialist and compared with computer gradin...

PURPOSE To identify local retinal abnormalities in diabetic patients with and without retinopathy, by using the multifocal electroretinogram (M-ERG). METHODS Electroretinograms were recorded at 103 discrete retinal locations in each eye of eight persons with nonproliferative diabetic retinopathy (NPDR) and eight diabetic persons without retinopathy, using VERIS (EDI, San Mateo, CA). The ampli...