Aberrant enzymatic activities or expression profiles of epigenetic regulations are therapeutic targets for cancers. Among these, histone 3 lysine 9 methylation (H3K9Me2) and global de-acetylation on histone proteins are associated with multiple cancer phenotypes including leukemia, prostatic carcinoma, hepatocellular carcinoma and pulmonary carcinoma. Here, we report the discovery of the first ...

Micromechanical cantilevers show great potential as highly sensitive biochemical sensors. Cantilever-based sensing involves the transduction of a biomolecular interaction to a measurable mechanical change in the cantilever resulting from induced surface stresses added mass. In surface stress sensing applications, one side of the cantilever beam is rendered sensitive to a specific target molecul...

Micromechanical cantilevers show great potential as highly sensitive biochemical sensors. Cantilever-based sensing involves the transduction of a biomolecular interaction to a measurable mechanical change in the cantilever resulting from induced surface stresses added mass. In surface stress sensing applications, one side of the cantilever beam is rendered sensitive to a specific target molecul...

Recent studies revealed that micro RNA-10b (mir-10b) is highly expressed in metastatic breast cancer cells and positively regulates breast cancer cell migration and invasion through inhibition of HOXD10 target synthesis. In this study we designed anti-mir-10b molecules and combined them with poly L-lysine (PLL) to test the delivery effectiveness. An RNA molecule sequence exactly matching the ma...

Engineered protein pores have several potential applications in biotechnology: as sensor elements in stochastic detection and ultrarapid DNA sequencing, as nanoreactors to observe single-molecule chemistry, and in the construction of nano- and micro-devices. One important class of pores contains molecular adapters, which provide internal binding sites for small molecules. Mutants of the alpha-h...

Micromechanical cantilevers show great potential as highly sensitive biochemical sensors. Cantilever-based sensing involves the transduction of a biomolecular interaction to a measurable mechanical change in the cantilever resulting from induced surface stresses added mass. In surface stress sensing applications, one side of the cantilever beam is rendered sensitive to a specific target molecul...

many studies on cold environments have been developed over the past two decades. highmountain freshwater presents high variability of nutrients and chemico-physical parameters, showing variations of ph, oxygen concentration, metals and temperature throughout the year. national park of sierra nevada (granada, spain) (37°032 n 03°182 w), has almost 40 lakes that are reported to be both endemic an...

The tissue engineering (TE) of dental oral tissue is facing significant changes in clinical treatments in dentistry. TE is based on a stem cell, signaling molecule, and scaffold triad that must be known and calibrated with attention to specific sectors in dentistry. This review article shows a summary of micro- and nanomorphological characteristics of dental tissues, of stem cells available in ...

A Mn4 single-molecule magnet is used to show that quantum tunneling of magnetization is not suppressed by moderate three-dimensional exchange coupling between molecules. Instead, it leads to an exchange bias of the quantum resonances which allows precise measurements of the effective exchange coupling that is mainly due to weak intermolecular hydrogen bonds. The magnetization versus applied fie...

Glutamate synthase (GltS, EC 1.4.1.13) forms with glutamine synthetase (GS, EC 6.3.1.2, reaction 1) the main route for glutamate synthesis in micro-organisms by catalysing the NAD(P)Hdependent transfer of the amide group of glutamine to the C(2) carbon of 2-oxoglutarate (2-OG, reaction 2). The overall reaction catalysed by GS and GltS (reaction 3) is similar to the reaction of glutamate dehydro...