A facile drug screening method based on synthesis of fluorescent gold nanoclusters inside albumin proteins loaded with small molecular drugs and comparing the relative fluorescence intensities of the resultant gold nanoclusters has been developed and successfully applied for the quantitative measurement of drug-protein binding constants.

Articles you may be interested in Interlayer exchange coupled composite free layer for CoFeB/MgO based perpendicular magnetic tunnel junctions J. Thermal stability and spin-transfer switchings in MgO-based magnetic tunnel junctions with ferromagnetically and antiferromagnetically coupled synthetic free layers Appl. Effect of interlayer coupling in CoFeB/Ta/NiFe free layers on the critical switc...

The geometric structure of MgO deposited on Fe(001) in ultrahigh vacuum by electron evaporation was determined in detail by using surface x-ray diffraction. In contrast to the common belief that MgO grows in direct contact on the Fe(001) substrate, we find an FeO interface layer between the substrate and the growing MgO structure which has not been considered thus far. This result opens new per...

A chemical approach to the formation of columnar defects involving the growth and incorporation of MgO nanorods into high temperature superconductors (HTS’s) has been developed. MgO nanorods were incorporated into Bi2Sr2CaCu2Oz, Bi2Sr2Ca2Cu3Oz, and Tl2Ba2Ca2Cu3Oz superconductors at areal densities up to 2 3 1010ycm2. Microstructural analyses of the composites demonstrate that the MgO nanorods c...

We have grown epitaxial single-crystal magnetotunnel junctions using Fe~001! substrates, MgO~001! spacers and Fe top electrodes. We have used scanning tunneling microscopy and atomic force microscopy to measure the tunneling characteristics as a function of position and demonstrated that local tunneling can be obtained such that the buried MgO can be characterized with nm resolution. Local I(V)...

In addition to its well-characterized role in the lens, αB-crystallin performs other functions. Methylglyoxal (MGO) can alter the function of the basement membrane of retinal pigment epithelial (RPE) cells. Thus, if MGO is not efficiently detoxified, it can induce adverse reactions in RPE cells. In this study, we examined the mechanisms underlying the anti-apoptotic activity of αB-crystallin in...

Extensive search for new magnetic materials free of critical rare-earth elements or expensive platinum suitable for technology or energy-applications is one of the main factors driving today's research in magnetism. Development of these new materials is often hindered by conventional bulk-synthesis techniques which result in phase mixtures or poor magnetic properties. This dissertation focusses...

Radiotherapy is often the most straightforward first line cancer treatment for solid tumors. While it is highly effective against tumors, there is also collateral damage to healthy proximal tissues especially with high doses. The use of radiosensitizers is an effective way to boost the killing efficacy of radiotherapy against the tumor while drastically limiting the received dose and reducing t...

The hydrogen peroxide dissociation on MgO(001) films deposited on Mo(001) surface is investigated by employing periodic density-functional theory methods. The pristine MgO(001) surface showing chemical inertness prefers the weak adsorbing molecular configuration and is extremely difficult to react with hydrogen peroxide. As far as we know, energetically favorable decomposition state of hydrogen...

Density functional theory calculations reveal that the work function of Au supported on MgO(001) is substantially reduced because of an interfacial dipole moment formed at the Au/MgO interface. Consequently, the Au/MgO interface plays an active role in the activation of O2 molecules by promoting charge transfer to the O2 2π* orbital. The presence of F-centers in the MgO substrate can further pr...