In this paper we study standard 3-fold conic bundles X/P and stable cubic del Pezzo fibrations X/P. These are the key examples of 3-fold Mori fibre spaces (Mfs). We begin systematically to chart the geography of these varieties, namely the classification of their deformation families and discrete invariants. Given a 3-fold Mfs X/S, we aim to understand the set of all Mfs Y/T with X birational t...

BACKGROUND The risk of aortic complications associated with pregnancy in women with Marfan syndrome (MFS) is not fully understood. METHODS AND RESULTS MFS women participating in the large National Registry of Genetically Triggered Thoracic Aortic Aneurysms and Cardiovascular Conditions (GenTAC) were evaluated. Among 184 women with MFS in whom pregnancy information was available, 94 (51%) had ...

The effect of magnetic field (MF) exposure on microcirculation and microvasculature is not clear or widely explored. In the limited body of data that exists, there are contradictions as to the effects of MFs on blood perfusion and pressure. Approximately half of the cited studies indicate a vasodilatory effect of MFs; the remaining half indicate that MFs could trigger either vasodilation or vas...

The Marfan syndrome (MFS) is a systemic connective tissue disorder caused by mutations in the FBN1 gene. Recent molecular studies, most performed in mouse models, revealed that the MFS is more a developmental abnormality with broad and complex effects on the morphogenesis and function of multiple organ systems. FBN1 haploinsufficiency and dysregulated transforming growth factor-beta (TGF-β) sig...

Epidemiologic studies have shown the relation between exposure to extremely low frequency magnetic fields (ELF-MFs) and childhood leukemia, so assessment of children exposure levels in different environments is considered as a serious precedence. Present study aimed at determining ELF-MFs flux densities near schools in Tehran. Measurements were performed near randomly selected schools in three ...

Ang II type 1a receptor (AT1aR)-mediated activation of MAPKs contributes to thoracic aortic aneurysm (TAA) development in Marfan syndrome (MFS). β-Arrestin2 (βarr2) is known to mediate AT1aR-dependent MAPK activation, as well as proproliferative and profibrotic signaling in aortic vascular smooth muscle cells. Therefore, we investigated whether βarr2-dependent signaling contributes to TAA forma...

BACKGROUND Myxofibrosarcoma (MFS) arises most commonly in the proximal extremities of the elderly, where it may involve subcutaneous and dermal tissues and masquerade as benign entities in limited biopsy samples. We encountered such a case, in which positivity for CD34 and morphologic features were initially wrongly interpreted as a 'low-fat/fat-free' spindle cell/pleomorphic lipoma. Case serie...

Human ventral temporal cortex (VTC) plays a pivotal role in high-level vision. An under-studied macroanatomical feature of VTC is the mid-fusiform sulcus (MFS), a shallow longitudinal sulcus separating the lateral and medial fusiform gyrus (FG). Here, we quantified the morphological features of the MFS in 69 subjects (ages 7-40), and investigated its relationship to both cytoarchitectonic and f...

740 words) Background: Infiltrative growth pattern is often observed in superficial myxofibrosarcoma (MFS) and undifferentiated pleomorphic sarcoma (UPS). According to the past literatures, radiographic infiltration of superficial MFS and UPS on magnetic resonance (MR) images indicates a high possibility of histologic infiltration. In recent years, this growth pattern has become widely recogniz...

BACKGROUND Aortic dissection (AoD) is a serious complication of thoracic aortic aneurysm (TAA). Relative risk for AoD in relation to TAA etiology, incidence, and pattern after prophylactic TAA surgery are poorly understood. OBJECTIVES This study sought to determine the incidence, pattern, and relative risk for AoD among patients with genetically associated TAA. METHODS The population includ...