metronidazole and it’s derivatives are drugs that have both antiprotozoal and anti bacterial effect.the reproductive toxicity of metronidazole has been shown in some studies. to investigate the effect of metronidazole on spermatogenesis in adult male rats, this study was designed. eighteen wistar male rats (70-90days old) were randomly divided into three groups. animals in group i (control grou...

BACKGROUND Bacterial vaginosis (BV) is one of the most common gynecological infections during reproductive age. Although metronidazole is one of the most effective medications recommended as the first-line treatment, it has various side effects. Because of the side effects and contraindications of some chemical medicines, using herbs has been investigated in treating BV. OBJECTIVES The aim of...

The objective of this study was to determine the stability of metronidazole benzoate suspension in SyrSpend SF One-Step Suspension system. The studied samples were packaged in 60-mL amber plastic prescription bottles, which were stored protected from light under controlled environmental conditions for a period of 360 days. Stability of metronidazole benzoate suspension in SyrSpend SF was assess...

BACKGROUND Metronidazole is the most commonly used drug for the treatment of giardiasis in humans. In spite of its therapeutic efficacy for giardiasis, low patient compliance, especially in children, side effects, and the emergence of metronidazole-resistant strains may restrict its use. Albendazole has been used to treat Giardia duodenalis infections in recent years. However, efficacy studies ...

conclusions this study reveals that garlic could be a suitable alternative for metronidazole in treatment of bv in those interested in herbal medicines or those affected by side effects of metronidazole. results amsel’s criteria were significantly decreased after treatment with garlic or metronidazole (70% and 48.3%, respectively; p < 0.001). therapeutic effects of garlic on bv were similar to ...

Title: Efficacy of single dose Gentamicin in combination with Metronidazole versus multiple doses for prevention of post caesarean infection Major points for revision Reviewer 1. The hypothesis being studied is that there is a difference in post-caesarean infections between a single dose of gentamicin in combination with metronidazole and multiple doses of gentamicin and metronidazole. In the b...

OBJECTIVES The aim of the investigation was to use in vitro transposon mutagenesis to generate metronidazole resistance in the obligately anaerobic pathogenic bacterium Bacteroides thetaiotaomicron, and to identify the genes involved to enable investigation of potential mechanisms for the generation of metronidazole resistance. METHODS The genes affected by the transposon insertion were ident...

In patients treated with FLAGYL, using a dosage regimen of 15 mg/kg loading dose followed 6 hours later by 7.5 mg/kg every 6 hours, the average peak steady-state plasma concentrations (Cmax) of metronidazole was 25 mcg/mL with trough (minimum) concentrations averaging 18 mcg/mL, respectively. Plasma concentrations of metronidazole are proportional to the administered dose. An eight-hour intrave...

To investigate amoxicillin and metronidazole resistance of Helicobacter pylori, we compared putative resistance genes between resistant strains obtained in vitro and their sensitive parent strain. All metronidazole-resistant strains had rdxA mutations, and an amoxicillin-resistant strain had pbp1 and pbp2 mutations. By transforming PCR products of these mutated genes into antibiotic-sensitive s...

We report the draft genome sequence of a Gardnerella vaginalis strain (3549624) isolated from a vaginal specimen. G. vaginalis is associated with bacterial vaginosis, the most common cause of vaginal discharge, which is often treated with metronidazole. This isolate is highly resistant to metronidazole (MIC, 500 µg/ml) and may be useful for comparative genomic studies to determine the molecular...