BACKGROUND With beta-blocker use becoming more prevalent in treating chronic heart failure (CHF), the choice of drugs raises important theoretical and practical questions. Although the second-generation compound metoprolol is beta1-selective, the third-generation compound carvedilol is beta-nonselective, with ancillary pharmacological properties including alpha-blockade and antioxidant effects....

BACKGROUND Metoprolol, a selective beta-1 blocker, is available in two different salt forms in the market - metoprolol succinate (MS) and metoprolol tartarate (MT). Both the formulations are Food and Drug Administration approved for the treatment of hypertension. Several studies have shown similar efficacies between the two salts; however, they differ in their pharmacokinetic properties and are...

Premenopausal women may be most vulnerable to acute coronary syndromes at a point in their menstrual cycle when their plasma estrogen levels are the lowest during and immediately after menstruation. Metoprolol is a first-line drug in the management of patients with acute coronary syndrome; however, when metoprolol was marketed in 1982, women were largely excluded from clinical trials. Furthermo...

OBJECTIVES The objective of this article is to compare blood pressure (BP)-lowing effects of nitrendipine and hydrochlorothiazide and nitrendipine and metoprolol, and estimate the economic effect of these therapies on hypertension. METHODS Outpatients (N = 793) 18-70 years of age with stage 2 or severe hypertension (SBP ≥ 160 mmHg and/or DBP ≥ 100 mmHg) were recruited from four randomly selec...

multi-drug therapy in high blood pressure is appreciated to achieve a normalblood pressure.a simple spectrophotometric method based on principal component analysis has been proposed for simultaneous determination of amlodipine (amd) and metoprolol(met) in pharmacutical preparations. calibration matrix contains 3.402 µgml -1 to 170.130 µgml -1 and from 13.060 µgml -1 to 65.3 µgml -1 amlodipine a...

OBJECTIVE To compare the effects of bisoprolol and metoprolol CR/ZOK (metoprolol succinate controlled release) on systolic blood pressure (bpsys) over a 24-h period in an in silico model. METHODS On the basis of the observed data from ambulatory blood pressure measurements (ABPM), a model with an appropriate distribution and correlation structure was derived for simulation of 24-h bpsys patte...

The aim of this study was to estimate the influence of chronic metoprolol treatment, which has been added to conventional heart failure, in patients with post infarction left ventricular dysfunction, on the effects of a one year physical training. Eighty-nine patients, who recently suffered myocardial infarction and also had left ventricular dysfunction with ejection fraction of 40% or less, we...

PURPOSE Atrial fibrillation with rapid ventricular response (RVR) is common during critical illness. In this study, we explore the comparative effectiveness of three commonly used drugs (metoprolol, diltiazem, and amiodarone) in the management of atrial fibrillation with RVR in the intensive care unit (ICU). METHODS Data pertaining to the first ICU admission were extracted from the Medical In...

An analytical method was developed to quantify a mixture of acetaminophen, metoprolol, methylparaben, carbamazepine, naproxen, estrone, estradiol, diclofenac, benzophenone, ibuprofen, progesterone, and mefenamic acid from domestic wastewater samples. To match fast efficient chromatographic separation for different classes compounds, an automated scouting liquid system associated with the experi...

Development and validation of spectrophotometric method for simultaneous estimation metoprolol succinate olmesartan medoxomil in tabletVachhani Kevin H, Patel Satish A