نتایج جستجو برای: methylguanine

تعداد نتایج: 2664  

Journal: :Proceedings of the National Academy of Sciences 1982

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Journal: :Biophysical Chemistry 2005

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Journal: :Oncology 2011

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Journal: :DNA Repair 2010

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Journal: :ACS medicinal chemistry letters 2012
Elrashied A E Garelnabi Dimitrios Pletsas Li Li Konstantinos Kiakos Nazira Karodia John A Hartley Roger M Phillips Richard T Wheelhouse

The imidazotetrazine ring is an acid-stable precursor and prodrug of highly reactive alkyl diazonium ions. We have shown that this reactivity can be managed productively in an aqueous system for the generation of aziridinium ions with 96% efficiency. The new compounds are potent DNA alkylators and have antitumor activity independent of the O6-methylguanine-DNA methyltransferase and DNA mismatch...

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Journal: :Biochemical Journal 1973

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Journal: :Oncology Letters 2015

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Journal: :Journal of Biological Chemistry 1990

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Journal: :Nucleic Acids Research 1991

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2011
Ying Huang Zakaria Rachid Bertrand J. Jean-Claude

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