We read with great interest the article by Largillier et al. [1] in which they analyzed prognostic factors in 1038 women with metastatic breast cancer. They did not show the importance of metastasis-free interval as a prognostic factor predicting survival from time of metastatic occurrence in their studies on contrary to other studies stating that early recurrence is an independent predictor of...

Apoptotic resistance is often associated with metastatic phenotype in tumor cells and is considered a hallmark of tumor progression. In this study, IFN regulatory factor 8 (IRF8) expression was found to be inversely correlated with an apoptotic-resistant and metastatic phenotype in human colon carcinoma cell lines in vitro. This inverse correlation was further extended to spontaneously arising ...

AIMS AND BACKGROUND The study was performed to assess the status of immunohistochemical markers in primary and metastatic breast cancer and to determine the organ-specific characteristics of metastatic breast cancer. METHODS Samples from 13 cases of paired primary and metastatic breast cancer and 34 cases of metastatic breast cancer were included. RESULTS In the analysis of 13 cases of pair...

A clinically relevant model of spontaneous breast cancer metastasis to multiple sites, including bone, was characterized and used to identify genes involved in metastatic progression. The metastatic potential of several genetically related tumor lines was assayed using a novel real-time quantitative RT-PCR assay of tumor burden. Based on this assay, the tumor lines were categorized as nonmetast...

The metastatic properties of tumor cell clones isolated from individual lesions of B16 melanoma metastatic to lung have been examined at different stages in the evolution of metastasis. Clonal analysis of metastatic lesions produced by B16 melanoma populations containing clones with identifiable, stable drug-resistance markers revealed that the majority (greater than 80%) of experimental metast...

OBJECTIVE We describe the case of a patient with metastatic breast cancer who presented with eyelid margin thickening and madarosis more suggestive of sebaceous cell carcinoma than metastatic disease. Histopathology confirmed metastatic breast adenocarcinoma. CASE REPORT A 59-year-old woman with a known history of metastatic breast carcinoma actively enrolled in a clinical trial presented wit...

Background: Bioactive compounds such as terpenoids, chondroitin sulfate, and polysaccharides with added value can be found in prestine marine creatures. These compounds often do have highly valuable therapeutic applications such as being antioxidant, antitumorogenic, anti-infl ammatory and anti-angiogenic. For the latter, varieties of angiogenesis factors can suppress this issu...

Metastatic calcinosis cutis is an uncommon complication of end-stage kidney disease but has severe and disabling effects. Its development attributed to disorders calcium phosphate metabolism associated with secondary hyperparathyroidism. The mainstay treatment remains medical therapy; however, in refractory cases a parathyroidectomy indicated. We describe the case 22-year-old female hyperparath...

A patient diagnosed with advanced lung cancer developed severe dyspnea after chemotherapy. Metastatic tumor completely obstructing the lower trachea was revealed by bronchoscopy. Emergent surgery required but it difficult to perform open tracheal and maintain sufficient ventilation intubation because of location size tumor. After consultation an esthesiologist, respiratory physician cardiothora...

In patients with high-risk metastatic neuroblastoma, the benefit of radiation therapy (RT) to metastatic sites as part of primary treatment has not been fully investigated. The purpose of this single-institution study was to evaluate local control of irradiated metastatic sites, and characterize metastatic disease burden and anatomic distribution in patients with high-risk metastatic neuroblast...