Efforts have been made to prove the safety of the traditional Siddha medicine, Kasha Gulanthaga Mathirai. Effects of Kasha Gulanthaga Mathirai in model organisms were not reported till date. This paper appraises a detail study of physio-chemical properties, phytochemical constituents and heavy metal contents of the selected drug [KGM]. The ICPOES reveals that the main metals present in the tabl...

Mercury is a toxic heavy metal which is widely dispersed in nature. Most human exposure results from fish consumption or dental amalgam. Mercury occurs in several chemical forms, with complex pharmacokinetics. Mercury is capable of inducing a wide range of clinical presentations. Diagnosis of mercury toxicity can be challenging but can be obtained with reasonable reliability. Effective therapie...

Metal-free magnetic resonance imaging (MRI) agents could overcome the established toxicity associated with metal-based agents in some patient populations and enable new modes of functional MRI in vivo. Herein, we report nitroxide-functionalized brush-arm star polymer organic radical contrast agents (BASP-ORCAs) that overcome the low contrast and poor in vivo stability associated with nitroxide-...

Metal-based drugs are largely undeveloped in pharmacology. One limiting factor is the systemic toxicity of metal-based compounds. A solid-phase, sequestratable delivery agent for local delivery of metals could reduce systemic toxicity, facilitating new drug development in this nascent area. Amorphous peroxotitanates (APT) are ion-exchange materials with high affinity for several heavy metal ion...

High throughput intracellular delivery strategies, electroporation, passive and TATHA2 facilitated diffusion of colloidal silver nanoparticles (AgNPs) are investigated for cellular toxicity and uptake using state-of-art analytical techniques. The TATHA2 facilitated approach efficiently delivered high payload with no toxicity, pre-requisites for intracellular applications of plasmonic metal nano...

Objective: Metal concentrations in 53 soil samples of Shahr-e-Babak were determined.  Methods: Assessment of enrichment factor and geo-accumulation index revealed higher degree of contamination of Cd, Pb, and Cu in soil samples. Moreover, results of metal fractionation study revealed high amount of Cd and Pb are associated in weakly bounds may lead to environmental risk of these metals.  Result...

The assessment of the risks exerted by nanoparticles is a key challenge for academic, industrial, and regulatory communities worldwide. Experimental evidence points towards significant toxicity for a range of nanoparticles both in vitro and in vivo. Worldwide efforts aim at uncovering the underlying mechanisms for this toxicity. Here, we show that the intracellular ion release elicited by the a...