Hollow spherical nanoparticles with ordered mesoporous silica shells were fabricated by evaporation-induced self-assembly using (NH(4))(2)SO(4) and cetyltrimethyl ammonium bromide (CTAB) as templates. The model drug, L-methionine, was encapsulated within the spherical void at high loadings by repeated crystallization.

Mesoporous silica nanoparticles with properly designed textural properties and tailored release of corrosion inhibitors are highly efficient smart carriers for advanced anticorrosive nanocomposite coatings.

The structural properties of mesoporous silica nanoparticles are reviewed. Different strategies for the introduction of functional groups are considered. Based on the architectural features of the material, the functionalization at defined regions of the particles is described, along with the properties emerging from the corresponding site-specific modifications of their chemistry. Many applica...

Mesoporous silica nanoparticles (MSNs) gained significant attention, particularly in the pharmaceutical field. Folic acid (FA) shows marked promise as a targeting agent for its specific interaction...

During last years the interest for nanotechnology and mesoporous silica materials has increased due to benefits that these materials can provide. Typical characteristics of mesoporous materials are a large surface area and pore volume, well-ordered and uniform pores with adjustable pores between 2 and 50 nm. Pore dimensions are comparable to many biological molecules, like enzymes, and may ther...

A multifunctional enveloped nanodevice based on mesoporous silica nanoparticle (MSN) was delicately designed for subcellular co-delivery of drug and therapeutic peptide to tumor cells. Mesoporous silica MCM-41 nanoparticles were used as the core for loading antineoplastic drug topotecan (TPT). The surface of nanoparticles was decorated with mitochondria-targeted therapeutic agent (Tpep) contain...

Due to uniquely ordered nanoporous structure and high surface area as well as large pore volume, mesoporous materials have exhibited excellent performance in both controlled drug delivery with sustained release profiles and formulation of poorly aqueoussoluble drugs with enhanced bioavailability. Compared with other bulk excipients, mesoporous materials could achieve a higher loading of active ...

Colloidal porous hosts in the form of microporous aluminosilicate (zeolite) or mesoporous silica nanoparticles are attractive materials for a wide range of potential applications, i.e. controlled release drug delivery systems. However, many fundamental challenges still remain in this relatively young research field. The following work focuses on overcoming some of the present limitations by dev...

BACKGROUND Mesoporous silica nanoparticles (MSNs) have several attractive properties as a drug delivery system, such as ordered porous structure, large surface area, controllable particle size as well as interior and exterior dual-functional surfaces. The purpose of this study was to develop novel lactosaminated mesoporous silica nanoparticles (Lac-MSNs) for asialoglycoprotein receptor (ASGPR) ...

Cancer is one of the fatal diseases in history humankind. In this regard, cancer immunotherapeutic strategies have revolutionized traditional mode treatment. Silica based nano-platforms been extensively applied nanomedicine including immunotherapy. Mesoporous silica nanoparticles (MSN) and mesoporous organosilica (MON) are attractive candidates due to ease controlling structural parameters as n...