Systemic sclerosis (SSc) is a rare chronic autoimmune disease characterized by vasculopathy, dysregulation of innate and adaptive immune responses, progressive fibrosis. SSc remains an orphan disease, with high morbity mortality in patients. The mesenchymal stromal cells (MSC) demonstrate vitro vivo pro-angiogenic, immuno-suppressive, anti-fibrotic properties appear as promising stem cell thera...

Multipotent mesenchymal stromal/stem cells (MSCs) reside in many human organs and comprise heterogeneous population of cells with self-renewal ability. These cells can be isolated from different tissues, and their morphology, immunophenotype, and differentiation potential are dependent on their tissue of origin. Each organ contains specific population of stromal cells which maintain regeneratio...

ex vivo expansion of human umbilical cord blood cells (hucbc) is explored by several investigators to enhance the repopulating potential of hucbc. the proliferation and expansion of human hematopoietic stem cells (hsc) in ex vivo culture was examined with the goal of generating a suitable clinical protocol for expanding hsc for patient transplantation. using primary human mesenchymal stem cells...

background: mesenchymal stem cells (mscs) with their potential to differentiate into mesodermal and non-mesodermal lineages have several immunomodulatory characteris-tics. these properties make them promising tools in cell and gene therapy. objective: to evaluate the potential therapeutic applications of autologous msc in improving clinical manifestations of ms patients. methods: ten patients w...

Back Cover: In article number 2200071, Kenneth Dalgarno and co-workers describe the reactive jet impingement bioprinting system as an effective strategy to deliver high cell concentrations directly onto metal surfaces with various topographies. Mesenchymal stromal cells are bioprinted in soft hydrogel matrices that provide extracellular matrix-like environment. The cell-laden hydrogels integrat...