Mesenchymal stem/stromal cells (MSC) are multipotent precursors endowed with the ability to home to primary and metastatic tumor sites, where they can integrate into the tumor-associated stroma. However, molecular mechanisms and outcome of their interaction with cancer cells have not been fully clarified. In this study, we investigated the effects mediated by bone marrow-derived MSC on human co...

Ewing sarcoma family tumors (ESFT) are aggressive bone and soft tissue tumors that express EWS-ETS fusion genes as driver mutations. Although the histogenesis of ESFT is controversial, mesenchymal (MSC) and/or neural crest (NCSC) stem cells have been implicated as cells of origin. For the current study we evaluated the consequences of EWS-FLI1 expression in human embryonic stem cell-derived NCS...

BACKGROUND AIMS Emerging evidence suggests human placental membrane is a valuable source of mesenchymal stromal cells (MSC). Amnion and chorion are tissues of early embryologic origin that may entail progenitor potential. These tissues are abundantly available and ethically unobjectionable and, because they are discarded post-partum, they can be widely used for extensive research and eventually...

multipotent mesenchymal stromal cells or mesenchymal stem cells (mscs) are mainly isolated from bone marrow or fat tissue. because of their potential of multilineage differentiation towards bone, cartilage and fat tissue, they were initially evaluated to develop innovative strategies for tissue engineering applications. more recently, they have gained interest based on their immunomodulatory pr...

objective(s)para-nonylphenol (p-np) is used in many industries and our previous study showed that p-np causes a reduction in rats bone marrow mesenchymal stem cells (mscs) viability. the aim of this study was to investigate the effect of p-np on osteogenic differentiation of mscs.materials and methodsmscs were isolated and expanded to 3rd passage, then cultured in dmem supplemented with osteoge...

objective: in this study we introduced an rgd-containing peptide of collagen iv origin that possesses potent cell adhesion and proliferation properties. this peptide was immobilized on a nanofibrous polycaprolactone/gelatin scaffold after which we analyzed human bone marrow-derived mesenchymal stem cells (hbmscs) adhesion and proliferation on this peptide-modified scaffold. methods: nanofibrous...

background: bone marrow mesenchymal stem cells (mscs) are one of the undifferentiated multipotential cell sources of human body. methods: mscs have the capacity to form a variety of cell types, especially chondrocytes and osteocytes. learning about responses of mscs to external milieu and chemical factors such as ph could recommend new approaches for preparation of suitable scaffolds for bone a...

Mesenchymal stem cells' (MSCs) fate is largely determined by the various topographical features and a range of extracellular matrix (ECM) components present in their niches. Apart from maintaining structural stability, they regulate cell morphology, division, proliferation, migration and differentiation among others. Traditional MSC cultures, which are mainly based on two-dimensional smooth sur...

Background: Diabetes mellitus is one of the main causes death due to complications that involve many organs such as heart, kidney, retina and others. Mesenchymal stem cell (MSC) has been demonstrated be effective in treatment diabetes. Aim work: To evaluate effect cells diabetic cardiomyopathy clarifying their role oxidative stress inflammation. Material methods: 30 adult male albino rats were ...

Transplantation of bone marrow stem cells into spinal cord lesions enhances axonal regeneration and promotes functional recovery in animal studies. There are two types of adult bone marrow stem cell; hematopoietic stem cells (HSCs), and mesenchymal stem cells (MSCs). The mechanisms by which HSCs and MSCs might promote spinal cord repair following transplantation have been extensively investigat...