Apparently without benefit of a predecessory symposium, the editor of this collection of monographs has selected several topics as representative of areas from which many of the future advances in the treatment of neoplastic disease will come forth. His choices are uniformly praiseworthy and meritorious. In each of the chapters, which cover such diversified approaches as interferons, monoclonal...

the many honorifics bestowed on the articles in this historical series, it is doubtful that any have had applied the best—funny. The rhetorical zest and smiling outrage that Joseph Berkson brings to his puncturing of the quasi-religious precepts of traditional statistics in his classic article 1 recalls for me a public debate I witnessed in the 1980s between a highly respected statistician and ...

A S announced in the previous special issue (IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING (TBME) LETTERS, vol. 58, no. 10, Part 1), we are pleased to present Part-2 of the IEEE TBME Letters Special Issue on Multiscale Modeling and Analysis in Computational Biology and Medicine. It complements Part-1 by introducing other meritorious research work in progress where computational modeling and analy...

We read with extreme interest the recently published work by O’Donnell and colleagues (May 2010). 1 Comparing lung volumes obtained using different techniques in a sample of patients with severe airfl ow limitation, the authors conclude that plethysmography systematically overestimates lung volumes with regard to gas dilution and thoracic imaging techniques. We believe it is meritorious to asse...

A fter holding the position of Associate F.ditor for 1 year, it seemed to me that offering some perspectives on the future of clinical research in orofacial pain would be a good idea. Enormous achievements m the treatment of acute illness have been witnessed in the past decades. However, it has become increasingly clear that many breakthrough interventions for acute illness have either no value...

Eight years' service as President of the Academy during a period which was almost exactly coterminous with the period of active preparedness for World War II, the war years, and the initial interval of transition to the postwar era could hardly help giving me as the chief executive officer a vivid insight into Academy operations in a time when its service functions and obligations were paramoun...

149 DAVID B. SHIRES (1931–2011) David Shires was Professor of Family Medicine and Community Health and Epidemiology at Dalhouaie University, Canada (1-3). Dr. Shires has practiced medicine in Africa, United Kingdom and United States and has been a resident in Canada for the past 20 years. His early work includes development of a computerized medical record system for the Apollo astronauts. Dr. ...

European countries, particularly the UK, have a long history of conducting birth cohort studies. Now a new birth cohort, the UK's Life Study, has ambitious plans to enroll tens of thousands of participants and a hope that it will succeed where its counterpart in the USA, the National Children's Study (NCS) has failed. 1 The NCS was dissolved in December 2014 by the Director of the National Inst...

My comments on the excellent paper “Total Right Heart Bypass: Long-Term Complications and Survival” by Lafuente et al. (1) performed at the Hospital Garrahan, which is a proud heir of the glorious Hospital de Niños, are accompanied by nostalgic feelings. The article is even more meritorious as it was conducted at a public hospital attended by low-income population (generally living far away fro...

Robert Jackson (Figure 1) was born in Toronto, Canada, in 1932 and grew up there. He received his medical degree from the University of Toronto in 1956. After a rotating internship, he did a year of research in the orthopaedic surgery department at one of the hospitals connected to the University of Toronto; for his work during that year on the proper management of fractures of the tibia, he re...