Histamine stimulates cAMP generating system in chick pineal gland J.Z. Nowak and B. Sgk Department o f Biogenic Amines, Polish Academy o f Sciences, P-225,90-950 t b d i , Poland INTRODUCTION AND METHODS. The pineal gland is the major organ for melatonin (MEL) production both in mammals and lower vertebrates, including birds. MEL biosynthesis shows a circadian rhythmicity: the hormone levels, a...

The Ca storing site for the carbachol-induced contraction in a high-K medium without adding CaCl2 was further investigated in the guinea pig taenia caecum. La3+ (0.05-0.5 mM) caused an increase in peak tension and relaxation rate in the carbachol contraction but reduced or abolished the response to CaCl2. Simultaneous application of carbachol and CaCl2 produced tension development the trace of ...

The effects of prednisolone, theophylline or salbutamol treatment were studied on leukocyte numbers in bronchoalveolar lavage (BAL) fluid taken 72 h after ovalbumin challenge in sensitized guinea pigs. Ovalbumin challenge resulted in an approximate 3-fold increase in the number of eosinophils in BAL fluid. This increase was significantly reduced by oral administration of prednisolone (59% inhib...

Histamine, released from activated mast cells, causes bronchoconstriction mediated by H1 receptors, whereas b2-agonists are widely used for the relief of bronchoconstriction. In this study, we examined the effects of the b2-adrenoceptor agonist, fenoterol, on the expression of H1 receptors at the mRNA and protein levels, and functional responses. Incubation of bovine tracheal smooth muscle with...